Which cancers are the most metastatic?
Answers from top 9 papers
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| Papers (9) | Insight |
|---|---|
269 Citations | The most common primary cancers that metastasize to the orbit are breast, prostate gland, and lung cancer. |
25 Citations | In our study, breast and lung cancers were the commonest primary cancers in metastatic bone disease. |
| Breast cancer, lung cancer, and leukemia were the most common cancers, while lung, breast, and stomach cancers caused most cancer deaths. Cancer is responsible for a substantial disease burden in the EMR, which is increasing. | |
| Though metastatic cancer might be the most common of these systemic conditions, its prevalence in … | |
| Lymph nodes, lung, liver, bone, and peritoneum are the most common metastatic sites of upper urinary tract urothelial cancers. | |
126 Citations | These results highlight the complexity of metastatic spreading, be it monoclonal or multiclonal, and suggest that most metastatic drivers are established in the primary tumor, despite the substantial heterogeneity seen in the metastases. |
61 Citations | In addition, the number of metastatic sites are remarkably less and incidental malignant tumours or multiple primary cancers are more frequent, indicating that cancer in centenarians carries a more indolent behaviour. |
| The metastatic assay may identify a molecular subgroup of primary prostate cancers with metastatic potential. | |
| This is highly important because the prognosis of histologically similar prostate carcinomas varies, thus creating a need to predict which cancers are most likely metastatic. |
Related Questions
What are the disparities in cancer metastasis by race?5 answersSignificant racial disparities exist in cancer metastasis patterns. Studies reveal that Black patients with lung cancer show varying metastatic site prevalence compared to White patients, with differences in brain, bone, and liver metastasis rates across different types of lung cancer. In metastatic lung adenocarcinoma, Hispanic/Latino patients exhibit lower rates of biomarker testing despite insurance coverage, indicating disparities in testing access. Racial gaps are also evident in the utilization of CDK4/6 inhibitors for metastatic breast cancer, with differences in treatment initiation over time and disparities in CDK4/6 inhibitor uptake between non-Hispanic White and non-Hispanic Black patients. Furthermore, in endometrial cancer, African-Americans have a higher risk of specific metastatic sites compared to Caucasians, emphasizing disparities in metastasis patterns across different histological subtypes. Lastly, Black women with residual ER+ breast cancer exhibit higher TMEM doorway density, potentially contributing to worse distant recurrence-free survival, highlighting racial disparities in metastasis risk.
How metastatic cancer kills?5 answersMetastatic cancer kills through a complex process involving various biological events. The tumor-stromal interface plays a crucial role in the initiation of metastasis, where tumor cells interact with stromal cells and undergo epithelial-mesenchymal transition (EMT). Circulating tumor cells (CTCs) are formed when tumor cells intravasate into the bloodstream, aided by stromal cross-talk and abnormal vasculature. CTCs can then adhere to secondary organs and form disseminative tumor cells (DTCs), which can either remain dormant or proliferate. The process of metastatic outgrowth is influenced by factors such as macrophage activity, impaired autophagy, and secondary site inflammation. Targeting metastasis can be achieved by repressing pre-metastatic niche formation, suppressing environmental stressors, and targeting signaling pathways and cell types involved in the metastatic process. These strategies can be used in combination with other therapies, such as immunotherapy, to limit the aggressive spread of metastatic cancer.
What are the most common types of breast metastasis?4 answersBreast metastasis can occur from various primary tumors. The most common types of breast metastasis include melanoma, lymphoma, lung carcinomas, gynecological carcinomas, and sarcomas. Other extramammary cancers that can metastasize to the breast include ovarian cancer, neuroendocrine tumors, and sarcomas. Invasive ductal carcinoma (IDC) is the most common histological type of breast cancer, and its most common sites of solitary metastasis are the lungs, bones, brain, and liver. Adrenal metastasis is rare in breast cancer, especially in IDC. Therefore, while breast metastasis can occur from various primary tumors, the most common types are melanoma, lymphoma, lung carcinomas, gynecological carcinomas, and sarcomas.
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