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Why combine ceftriaxone and azithromycin in pneumonia? 

Biofilm
Cefixime
Neisseria gonorrhoeae
Colistin
Levofloxacin
Best insight from top research papers

Combining ceftriaxone and azithromycin in pneumonia treatment is supported by various studies. Azithromycin, a macrolide, is commonly used in pneumonia treatment due to its efficacy in achieving clinical stability in patients with community-acquired pneumonia (CAP) . Additionally, azithromycin has shown effectiveness in inhibiting biofilm growth in bacterial pathogens like Klebsiella pneumoniae, enhancing the action of last-resort antibiotics like colistin methanesulfonate against biofilms . On the other hand, ceftriaxone, a β-lactam, when combined with azithromycin, has demonstrated positive outcomes in mild to moderate CAP cases, improving patients' signs and symptoms and reducing hospitalization length . The combination therapy's effectiveness is further supported by the European Gonococcal Antimicrobial Surveillance Programme, which recommends dual therapy with ceftriaxone and azithromycin for certain cases, emphasizing the importance of monitoring antimicrobial resistance for optimal treatment outcomes .

Answers from top 5 papers

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Papers (5)Insight
Open access•Journal Article•DOI
Azithromycin possesses biofilm–inhibitory activity and potentiates non-bactericidal colistin methanesulfonate (CMS) and polymyxin B against Klebsiella pneumonia
Olena Moshynets, Taras P. Baranovskyi, Scott J. Cameron, Olga Iungin, Ianina Pokholenko, Robyn Jerdan, Aleksandr Kamyshnyi, Alexey A. Krikunov, V. V. Potochilova, K Rudnieva, Andrew J. Spiers 
01 Jul 2022-PLOS ONE
2 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Study on the Therapeutic Effect of Azithromycin Combined with Glucocorticoid on Pulmonary Function and Inflammatory Response in Children with Pneumonia
Qingchun Zhao, Junbo Yang, Yongmei Sheng, Min-tuo Zhuang, Minglu Qi 
27 Mar 2022-Journal of Healthcare Engineering
2 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Clinical Effectiveness and Outcomes of Azithromycin versus Doxycycline Containing Regimen in Inpatients with Community Acquired Pneumonia: A Retrospective Cohort Study
R. C. PEDRECAL JÚNIOR
04 May 2023-Journal of Clinical Pharmacy and Therapeutics
Combining ceftriaxone and azithromycin in pneumonia is effective for achieving clinical stability in inpatients, as supported by comparable outcomes to doxycycline-containing regimens in the study.
Open access•Journal Article•DOI
Levofloxacin versus ceftriaxone and azithromycin for treating community-acquired pneumonia: a randomized clinical trial study
Davood Yadegarynia, Shabnam Tehrani, Fatemeh Nejad Maghsoudi, Fatemeh Shojaeian, Amirreza Keyvanfar 
01 Aug 2022-Iranian journal of microbiology
Combining ceftriaxone and azithromycin in pneumonia treatment aims to compare efficacy and side effects with levofloxacin, showing similar side effects but potentially inferior clinical outcomes.
Open access•Journal Article•DOI
Significant increase in azithromycin “resistance” and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019
Michaela Day, Susanne Jacobsson, Gianfranco Spiteri, Carina Kulishev, Noshin Sajedi, Neil Woodford, Benjamin Blumel, Marieke J. van der Werf, Andrew J Amato-Gauci, Michelle J Cole, C. Eder, Sonja Pleininger, Steliana Huhlescu, Irith De Baetselier, Blaženka Hunjak, Tatjana Nemeth Blažić, Panagiota Maikanti-Charalampous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, R. Peetso, Jelena Viktorova, Ndeindo Ndeikoundam, Béatrice Berçot, Anu Patari Sampo, V. Kirjavainen, Susanne Buder, Klaus Jansen, Vivi Miriagou, Eszter Balla, Maria E. Dudas, Gudrun Sigmundsdottir, Lena Rós Ásmundsdóttir, Sinéad Saab, Brendan M. Crowley, Anna Carannante, Paola Stefanelli, Gatis Pakarna, Violeta Mavcutko, Robert Cassar, Christopher Barbara, F. Vella, Alje P. van Dam, Ineke Linde, Dominique A. Caugant, Hilde Kløvstad, Beata Młynarczyk-Bonikowska, Maria José Borrego, Peter Pavlik, Irena Klavs, T. Kustec, Julio A. Vázquez, Asunción Reynoso Díaz, Raquel Abad Torreblanca, Inga Velicko, Magnus Unemo, Helen Fifer, Kate Templeton 
07 Jun 2022-BMC Infectious Diseases
14 Citations
Not addressed in the paper.

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Can I take azithromycin and zinc together?6 answers
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