Why is primary ciliary density important?
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Primary ciliary density is crucial due to its role in various physiological processes. Studies highlight the significance of primary cilia in sensory signal transduction, neuronal maturation, and cellular signaling pathways in different tissues, including the visual system, neural stem cells, and skeletal tissues . Primary cilia act as cellular antennas, sensing a wide array of signals and regulating developmental pathways, such as the sonic hedgehog pathway, during neuronal development and adult neuronal function. Maintaining optimal ciliary density is essential for proper neuronal function, neurogenesis, and organ development, emphasizing the importance of primary cilia in overall cellular health and tissue homeostasis. Additionally, primary cilia play a critical role in mechanosensation, mechanotransduction, and cellular behaviors, further underlining the significance of primary ciliary density in various physiological contexts .
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| Papers (4) | Insight |
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8 Citations | Primary ciliary density is crucial for optimal neuronal function in the superior colliculus and dorsal lateral geniculate nucleus, aiding in neuronal maturation and function in the visual pathway. |
| Primary ciliary density is crucial as it influences mechanosensation, polarity maintenance, and cell behaviors in skeletal development and diseases, highlighting its significance in pathogenesis and potential therapeutic interventions. | |
11 Citations | Primary ciliary density is crucial as cilia regulate metabolic processes, including white adipose tissue expansion during obesity, by sensing and transducing various signals specific to different cell types. |
3 Citations | Primary ciliary density is crucial for signaling pathways in neural stem/progenitor cells and neurons, impacting developmental processes, neuronal function, and memory formation, as indicated in the research. |
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