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Why microwave irradiation process superior over conventional method in synthesis of pyrimidine?

Knoevenagel condensation

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Microwave irradiation is superior to the conventional method in the synthesis of pyrimidine due to several reasons. Firstly, microwave-assisted reactions offer a faster rate of reaction and reduced reaction time, resulting in higher product yield . Secondly, microwave irradiation provides a cleaner reaction with improved product yield compared to conventional synthesis . Additionally, microwave-assisted methods are environmentally friendly and follow a green protocol, as they involve the use of recyclable organic solvents . Moreover, microwave-assisted synthesis is advantageous in medicinal chemistry research, as it is less time-consuming and crucial in drug discovery and development . Lastly, microwave irradiation allows for the synthesis of pyrimidine derivatives with diverse biological activities, making it a valuable tool in the development of therapeutic compounds .

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Open access•Journal Article•DOI Microwave Irradiated Eco-friendly Synthesis of Pyrimidine Derivatives as Potential Antitubercular Agents Krishna Chandra Panda, B. Ravi Kumar, Biswa Mohan Sahoo, Bimal K. Banik, Abhishek R. Tiwari - Show less +4 more 01 Jan 2022-Asian Journal of Chemistry 3 Citations	The microwave irradiation process is superior to the conventional method in the synthesis of pyrimidine because it offers a cleaner reaction, shorter reaction time, and improved product yield. (28 words)
Journal Article•DOI Solvent-free rapid microwave synthesis and antiviral activity of 2,4-(i h, 3h)pyrimidinedione 04 Jan 2023-Pakistan journal of science	The microwave-assisted method is superior to the conventional method in the synthesis of pyrimidine because it provides better yield, reduced reaction time, and safe and environment-friendly conditions.
Journal Article•DOI Conventional vs. microwave-assisted synthesis: A comparative study on the synthesis of tri-substituted imidazoles Deepali A. Bansode, Tanvi Goel, Naman Jain - Show less +2 more 05 Jan 2023-Current microwave chemistry	The provided paper is about the synthesis of tri-substituted imidazoles, not pyrimidines. Therefore, there is no information in the paper about why microwave irradiation is superior to the conventional method in the synthesis of pyrimidines.
Journal Article•DOI Microwave Induced Green Synthesis: Sustainable Technology for Efficient Development of Bioactive Pyrimidine Scaffolds. Biswa Mohan Sahoo, Bimal K. Banik, B. Ravi Kumar, Krishna Chandra Panda, Abhishek R. Tiwari, Varsha Tiwari, Sunil Singh, Manish Kumar - Show less +7 more 22 Jun 2022-Current medicinal chemistry 2 Citations	Microwave irradiation is superior to conventional methods in pyrimidine synthesis due to its faster reaction rate, easier work-up procedure, higher product yield, and reduced environmental pollution.

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