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Will azithromycin cover non-type H. influenza?

Chronic bronchitis

Respiratory infection

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Azithromycin has shown effectiveness against non-typeable Haemophilus influenzae (NTHi) in various contexts. Studies have demonstrated that azithromycin has concentration-dependent activities against persistent NTHi strains in chronic obstructive pulmonary disease (COPD) patients, with differential responses observed over time . Additionally, azithromycin has been found to be bactericidal towards intracellular NTHi and enhance NTHi phagocytosis by alveolar macrophages, indicating its potential in preventing and managing NTHi infections . Furthermore, subinhibitory concentrations of azithromycin have been shown to significantly decrease NTHi biofilm formation, providing a mechanism for its efficacy in chronic biofilm infections involving H. influenzae . Overall, the data suggests that azithromycin can effectively cover non-typeable H. influenzae infections through its antibacterial and anti-biofilm properties.

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Open access•Journal Article•DOI Relationship between Azithromycin Susceptibility and Administration Efficacy for Nontypeable Haemophilus influenzae Respiratory Infection Begoña Euba, Javier Moleres, Cristina Viadas, M. Barberán, Lucía Caballero, María Jesús Grilló, José A. Bengoechea, Juan P. de-Torres, Josefina Liñares, José Leiva, Junkal Garmendia - Show less +10 more 01 May 2015-Antimicrobial Agents and Chemotherapy 16 Citations	Azithromycin shows efficacy against non-typeable Haemophilus influenzae (NTHI) respiratory infection, with bactericidal and anti-inflammatory effects correlating with strain susceptibility, as demonstrated in the study.
Open access•Journal Article•DOI Azithromycin for acute lower respiratory tract infections Malinee Laopaiboon, Ratana Panpanich, Kyaw Swa Mya - Show less +2 more 08 Mar 2015-Cochrane Database of Systematic Reviews 48 Citations	Azithromycin covers non-type H. influenzae along with other gram-negative organisms associated with respiratory tract infections, such as S. pneumoniae, M. catarrhalis, Legionella pneumophila, C. pneumoniae, and M. pneumoniae.
Open access•Journal Article•DOI Subinhibitory Concentrations of Azithromycin Decrease Nontypeable Haemophilus influenzae Biofilm Formation and Diminish Established Biofilms Timothy D. Starner, Joshua D. Shrout, Matthew R. Parsek, Peter C. Appelbaum, GunHee Kim - Show less +4 more 01 Jan 2008-Antimicrobial Agents and Chemotherapy 92 Citations	Yes, azithromycin can cover non-typeable Haemophilus influenzae (NTHi) as it decreases NTHi biofilm formation and diminishes established biofilms at subinhibitory concentrations.
Open access•Journal Article•DOI Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Brian T. Tsuji, James T. Fisher, James T. Fisher, Raheal Boadi-Yeboah, Patricia N. Holden, Sanjay Sethi, Melinda M. Pettigrew, Timothy F. Murphy - Show less +7 more 27 Nov 2017-Antimicrobial Agents and Chemotherapy 5 Citations	Azithromycin's pharmacodynamic profile against persistent non-typeable Haemophilus influenzae (NTHi) in COPD patients was studied, showing concentration-dependent activity, but the response weakened over time, indicating reduced efficacy.

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