Showing papers on "Angiogenesis published in 1974"

Proceedings: Tumor angiogenesis factor.

Abstract: Summary Recent evidence from our studies indicates that solid tumor growth is not continuous but that it can be separated into two stages, avascular and vascular. In the avascular stage, tumors remain dormant at diameters of 1 to 2 mm. Further growth is possible only after new capillaries have been elicited from the host and have penetrated the tumor. This capillary proliferation is stimulated by a diffusible factor, tumor angiogenesis factor, released by solid tumors, and by neoplastic cells in culture. The biology and isolation of tumor angiogenesis factor are discussed. Evidence for the mechanism of tumor dormancy in the absence of angiogenesis will be presented. Therapeutic implications of the inhibition of tumor angiogenesis will be mentioned briefly.