Showing papers on "Antitussive Agent published in 1969"

Codeine and its alternates for pain and cough relief: 3. The antitussive action of codeine—mechanism, methodology and evaluation

Abstract: This report-the third of a series on codeine and its alternates for pain and cough relief-presents a detailed review of the physiology and pathophysiology of cough, the methods for the experimental and clinical measurement of the antitussive action of drugs, possible mechanisms of action of antitussive agents, and includes a compilation of experimental results and clinical experience with codeine as an antitussive.

Codeine and its alternates for pain and cough relief. 5. Discussion and summary.

Abstract: This chapter concludes the survey of experimental and clinical data on the analgesic and antitussive properties of codeine and its potential therapeutic alternates. From an evaluation of their effectiveness on the one hand and the side-effects, including tolerance, dependence and abuse liability on the other, it would appear that the therapeutic goals of codeine could be achieved by other substances, except perhaps where analgesia, cough relief, and sedation are required simultaneously. The use of these other substances would, however, result in no particular gain and probably no particular loss.

Basically substituted cycloalkene compounds as antitussive agents

Abstract: THE ANTITUSSIVE COMPOSITION WHICH COMPRISES SPECIFIC CYCLOALKENE COMPOUNDS AND A PHARMACEUTICAL EXCIPIENT.

Pharmaceutical compositions containing benzothiophene derivatives

Abstract: BENZOTHIOPHENE DERIVATIVES HAVING THE STRUCTURAL FORMULA DESCRIBED BELOW, A METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. THESE PREPARATIONS ARE USEFUL AS ANALGESIC, ANTIPYRETIC, ANTIINFLAMMATORY, ANTITUSSIVE AGENTS, AS LOCAL ANAESTHETICS AND ANTISPASMODIC AND ANTIHISTAMINIC AGENTS. THEY HAVE THESE PROPERTIES COMBINED WITH RELATIVELY LOW TOXICITY. THEY MAY, THEREFORE, BE USED FOR THE RELIEF OF PAIN, INFLAMMATION, PYRESIS OF VARIOUS ORIGINS, OR TUSSIVE IRRITATION.

2-alkanoyl or benzoyl-3-tertiaryamino alkoxy-benzothiophenes

Abstract: BENZOTHIOPHENE DERIVATIVES HAVING THE STRUCTURAL FORMULA DESCRIBED BELOW, A METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. THESE PREPARATIONS ARE USEFUL AS ANALGESIC, ANTIPYRETIC, ANTIINFLAMMATORY ANTITUSSIVE AGENTS, AS LOCAL ANAESTHETICS AND ANTISPASMODIC AND ANTIHISTAMINIC AGENTS. THEY HAVE THESE PROPERTIES COMBINED WITH RELATIVELY LOW TOXICITY. THEY MAY THEREFORE, BE USED FOR THE RELIEF OF PAIN, INFLAMMATION, PYRESIS OF VARIOUS ORIGINS, OR TUSSIVE IRRITATION.