Showing papers on "Arecoline published in 1967"
TL;DR: Atropine, added in vitro prior to the addition of the tremorgenic agent, prevents the increase in acetylcholine which normally occurs in the brain homogenate, and the present work extends previous experiments with arecoline.
Abstract: The two alkaloids, arecoline and nicotine, share the property of being used as stimulants by large portions of the world population (Larson, Haag & Silvette, 1961; Lewin, 1889). Both have also been used experimentally to produce tremor in animals as a way ot screening of drugs against Parkinson's disease (Anichov, 1959; Bovet & Longo, 1951). In a previous investigation, it was demonstrated that tremorgenic agents with muscarine-like activity give rise to increases in total brain acetylcholine (Holmstedt & Lundgren, 1966). The values return to normal and the tremor disappears at about the same time. Atropine, given before or after the tremorgenic agents, counteracts the tremor and the increase in brain acetylcholine, whereas methylatropine only abolishes the peripheral cholinergic symptoms. In the same investigation, it was observed that arecoline (lo-' M ) or oxotremorine (10"!M), when added to a brain homogenate treated with physostigmine (eserine), caused a considerable increase in acetylcholine. Atropine, added in vitro prior to the addition of the tremorgenic agent, prevents the increase in acetylcholine which normally occurs in the brain homogenate. The present work extends previous experiments with arecoline. It also includes work with arecoline methiodide, nicotine, and structurally related compounds.
43 citations
TL;DR: The data indicate that in addition to earlier described monoaminergic pathways mediating inhibition of oestrous behaviour, cholinergic mechanisms are also involved.
Abstract: The effects of pilocarpine, oxotremorine and arecoline were studied on oestradiol/progesterone activated oestrous behaviour in ovariectomized rats. A heat-inhibitory effect was obtained, which could be more effectively counteracted by atrophie than methyl-atropine.
31 citations
TL;DR: A series of arecoline-like aldoximes were synthesized and evaluated as potential reactivators of organophosphate-inhibited cholinesterase, showing that although these a Aldoximes are less toxic than the quaternary ald oximes, they are much less effective as reactivator.
13 citations
9 citations
Journal Article•
7 citations
TL;DR: It was given as a conclusion that pilocarpine and arecoline accelerated the acetylcholine liberation to contract the ileum and that 1-ascorbic acid depressed the acetylene liberation from the guinea pig ilesum.
Abstract: The mode of action of pilocarpine, arecoline and 1-ascorbic acid was studied on the isolated ileum of the guinea pig. It was given as a conclusion that pilocarpine and arecoline accelerated the acetylcholine liberation to contract the ileum and that 1-ascorbic acid depressed the acetylcholine liberation from the guinea pig ileum.
7 citations