Showing papers on "Chronic gastritis published in 1975"
TL;DR: Various areas of research pertaining to this entity, including that from the author's laboratory, are reviewed, encompassing histological and ultrastructural abnormalities, enzyme histochemistry, and exfoliative cytology and cytochemistry of chronic gastritis, with emphasis on the diagnostic significance of these laboratory methods.
75 citations
TL;DR: To elucidate the histogenesis of gastric cancer preceded by “chronic gastritis”, 67 foci of minute cancer less than 5 mm in largest diameter were examined histologically and all the minute cancers were found in the transitional zone between foveolar epithelium and pyloric glands corresponding to “generative cell layer” in autoradiographic studies.
Abstract: In order to elucidate the histogenesis of gastric cancer preceded by "chronic gastritis", 67 foci (58 cases) of minute cancer less than 5 mn in largest diameter were examined histologically. The results obtained were as follows: (1) Except in two cases, all minute cancerous foci were found unexpectedly in the mucosa of the antrum or of the angulus having peptic ulcer or gastric cancer. They were more frequent in the lesser curvature than in other parts of the stomach. (2) Histologically, 18 foci were found in an area close to the main lesion, while 40 were far from the lesion. Seven foci were detected in the mucosa adjacent to ulcer scars. (3) In retrospective macroscopical examinations, 41 foci showed minimal erosion or tiny depressions on the affected mucosa, while in the other 26 no recognizable changes were observable. (4) Histologically, the gastric mucosa outside the cancer lesions was more or less atrophic with or without intestinal metaplasia. (5) Regardless of histological types, all the minute cancers were found in the transitional zone between foveolar epithelium and pyloric glands corresponding to "generative cell layer" in autoradiographic studies. (6) Poorly differentiated adenocarcinomas containing signet-ring cells occurred most often in combination with no or slight intestinal metaplasia of the mucosa, while well-differentiated adenocarcinomas were always found in ventricles with severe intestinal metaplasia.
67 citations
TL;DR: Gastric mucosal biopsy specimens from 241 patients with examined found chronic inflammatory cellular infiltration of the gastric mucosa was found in 181 patients and this graded as mild, moderate or severe.
Abstract: Gastric mucosal biopsy specimens from 241 patients with examined. Chronic inflammatory cellular infiltration of the gastric mucosa was found in 181 patients and this graded as mild, moderate or severe. The presence or absence of atrophy or intestinal metaplasia was noted. True superficial gastritis was observed in only three cases.
20 citations
TL;DR: It appeared that the subjects belonging to carcinoma mucocellulare index patient families had a significantly higher susceptibility to chronic gastritis than the other relatives examined, and were significantly concentrated in the group of 'high risk' families.
Abstract: The morphological state of gastric body mucosa was examined in 269 first-degree relatives of 64 index patients with gastric carcinoma and in 142 subjects selected at random. Gastric carcinoma was divided into three groups according to histological properties: carcinoma mucocellulare, carcinoma adenomatosum, and carcinoma anaplasticum. The state of gastric body mucosa was divided into five stages: normal, superficial gastritis, slight moderate, and severe atrophic gastritis. The results were subjected to the numerical analysis based on the stochastic theory. The term 'age-adjusted score' (AAS) employed therein defines the individual susceptiability to chronic gastritis. In terms of AAS, the material could be divided into 'high' and 'low' gastritis risk families. It appeared that the subjects belonging to carcinoma mucocellulare index patient families had a significantly higher susceptibility to chronic gastritis than the other relatives examined. These families were also significantly concentrated in the group of 'high risk' families. The heterogeneity of the relatives of gastric cancer patients as regards their gastritis risk should obviously be taken into account in future epidemiological studies. These findings constitute further justification of the genetic approach in studies concerning gastritis-gastric cancer relationship.
14 citations
Journal Article•
TL;DR: In one patient an essentially normal mucosa was found in all biopsy specimens, in other patients parietal cells reappeared without any specific therapy, and in 5 patients regression of chronic atrophic gastritis was seen.
Abstract: In 36 patients step-wise biopsies of gastric mucosa were performed in 1971 and in 1974/75. A comparison of the histological changes revealed identical findings in 15, progression of superficial gastritis in 9 and regression of superficial gastritis in 7. In 5 patients regression of chronic atrophic gastritis was seen. In one patient an essentially normal mucosa was found in all biopsy specimens, in other patients parietal cells reappeared without any specific therapy.
13 citations
TL;DR: Immunochemical studies demonstrated no identity of AGP with human “gastrointestinal tumor associated antigens” and in 7 out of 17 AGP positive samples immunochemical differences between gastric and serum AGP were observed.
Abstract: Gastric juice was neutralized (nGJ)in vivo by 80 ml of a phosphate buffer containing radiolabelled vitamin B12 as dilution indicator Unprocessed nGJ was analyzed in the double gel diffusion technique for the presence of serum proteins using monospecific antiseraα1-Acid glycoprotein (AGP) was found in a high incidence (36 out of 38 subjects) in nGJ of gastric cancer patients AGP was also observed less frequently in nGJ of patients with Billroth II resections (6/15), metaplasia (11/52), gastric ulcer (3/24), chronic atrophic gastritis (2/26) and chronic gastritis (3/63) AGP was absent in the control group (0/21), in patients with surface gastritis (0/38) and in subjects with normal acid secretion (0/45) Immunochemical studies demonstrated no identity of AGP with human “gastrointestinal tumor associated antigens” In 7 out of 17 AGP positive samples immunochemical differences between gastric and serum AGP were observed
5 citations
TL;DR: The high frequency of chronic gastritis occurring in patients with gastric ulcer in the present series suggests that chronic Gastritis may be an important aetiological factor in the pathogenesis of gastric Ulceration.
Abstract: Summary: Multiple gastric biopsies were performed with a duodenofiberscope in 58 Chinese subjects. All 58 cases had a gastric ulcer crater, demonstrated by endoscopy, or barium meal, or both. Histological sections of the gastric biopsies showed chronic atrophic gastritis in 12 (20.6%), chronic gastritis in 31 (53.4%), and acute-on-chronic gastritis in 11 (19%). Only two cases or 3.4% had normal gastric mucosa, while 54 cases or 93% had some form of chronic gastritis, on the gastric biopsy. The gastritis was associated with intestinal metaplasia in 16 cases (27.6%), while two cases had histological evidence of gastric atypia. No significant difference was found in the mean basal and peak acid outputs among the three groups of gastric ulcer cases with chronic atrophic gastritis, chronic gastritis, and acute-on-chronic gastritis. The high frequency of chronic gastritis (93%) occurring in patients with gastric ulcer in the present series suggests that chronic gastritis may be an important aetiological factor in the pathogenesis of gastric ulceration.
4 citations
Journal Article•
TL;DR: Stats indicated that chronic superficial gastritis and chronic atrophic gastritis are not associated with reduced gastric acid secretion in Chinese subjects and combinations of the groups of patients with various types of gastritis showed no significant difference.
2 citations
Journal Article•
TL;DR: Transfer of autoimmune gastritis by lymphocytes from the ductus thoracicus lymph of sick animals to non-immunized animals does support the hypothesis that autoimmune processes are involved in the pathogenesis of atrophic gastritis.
Abstract: The role of autoimmune processes in the pathogenesis of atrophic gastritis, be it with or without pernicious anemia, is described on the basis of literature data. Various findings in cases of atrophic gastritis favor such a role, e.g. histological findings, the high incidence of autoantibodies against gastric mucosa, a high specificity of gastric antigens in cellular immune reactions, the concomitant occurrence of other auto-immune diseases, the favorable effect of immunosuppressive therapy. On an experimental basis transfer of autoimmune gastritis by lymphocytes from the ductus thoracicus lymph of sick animals to non-immunized animals does support this hypothesis.
1 citations