Showing papers on "Demethylase published in 1973"
TL;DR: N-Oxidation of N,N-dimethylaniline and oxidative demethylation of aminopyrine were studied in human liver hornogenates and neither activity was preferentially influenced by a specific disease process, but both decreased upon severe tissue damage.
Abstract: 1. N-Oxidation of N,N-dimethylaniline and oxidative demethylation of aminopyrine were studied in human liver hornogenates. At their respective pH optima (8·4 for N-oxidase and 7·4 for demethylase) N-oxidase activity was higher than that of demethylase in the majority of biopsies assayed.2. Neither activity was preferentially influenced by a specific disease process, but both decreased upon severe tissue damage. There was no apparent relationship of either activity with age or sex.3. Demethylase activities were highest in patients exposed to barbiturates, and increased N-oxidase activity was observed in patients exposed to amphetamines and some tranquilizers.
65 citations
TL;DR: There are no striking differences in relative thermolability or ontogenetic expression among these four closely linked aromatic hydrocarbon-induced mono-oxygenase activities.
64 citations
TL;DR: The results add to existing evidence that phenobarbital and 3-methylcholanthrene produce their inductive effects by different mechanisms and raise the possibility that cytochrome P 1 -450 may be synthesized in both RER and SER.
17 citations
TL;DR: Hepatic cells from chick embryo levers were grown in primary monolayer cell cultures and the addition of allylisopropylacetamide and phenobarbital increased the chlorcyclizine N -demethylase activity and cytochrome P-450 content, and this stimulation was prevented by the added of inhibitors of protein and RNA synthesis.
7 citations