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Ida S. Owens
Researcher at National Institutes of Health
Publications - 74
Citations - 6331
Ida S. Owens is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Isozyme & Glucuronidation. The author has an hindex of 36, co-authored 74 publications receiving 6188 citations.
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Journal ArticleDOI
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
Peter I. Mackenzie,Ida S. Owens,Brian Burchell,Karl Walter Bock,Amos Marc Bairoch,Alain Bélanger,Sylvie Fournel-Gigleux,Mitchell D. Green,Dean W. Hum,Takashi Iyanagi,Doron Lancet,Pierre Louisot,Jacques Magdalou,Jayanla Roy Chowdhury,Joseph K. Ritter,Harry Schachter,Thomas R. Tephly,Keith F. Tipton,Daniel W. Nebert +18 more
TL;DR: This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution and is anticipated that this UGT gene nomenClature system will require updating on a regular basis.
Journal ArticleDOI
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Peter I. Mackenzie,Karl Walter Bock,Brian Burchell,Chantal Guillemette,Shinichi Ikushiro,Takashi Iyanagi,John O. Miners,Ida S. Owens,Daniel W. Nebert +8 more
TL;DR: The UGT nomenclature is updated to include new genes identified in the human, mouse and rat genomes and in other mammalian species to prevent confusion when the same gene is given different names.
Journal ArticleDOI
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.
Joseph K. Ritter,Fan Chen,Y. Y. Sheen,H. M. Tran,Shigeru Kimura,Matthew T. Yeatman,Ida S. Owens +6 more
TL;DR: It is reported that the two corresponding bilirubin transferases and the phenol transferase are encoded by a novel locus, UGT1, which is also predicted to encode three other bilirUBin transferase-like isozymes all having identical carboxyl termini.
Journal ArticleDOI
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.
Junko Sugatani,Hiroyuki Kojima,Akiko Ueda,Satoru Kakizaki,Kouichi Yoshinari,Qi Hui Gong,Ida S. Owens,Masahiko Negishi,Tatsuya Sueyoshi +8 more
TL;DR: The UDP‐glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid and was effectively activated in mouse primary hepatocytes in response to phenobarbital.
Journal ArticleDOI
Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.
Qi-Hui Gong,Jeong W. Cho,Theresa Huang,Christine Potter,Nahid Gholami,Nikhil K. Basu,Shigeki Kubota,Sheryl Carvalho,Matthew W. Pennington,Ida S. Owens,Nicole C. Popescu +10 more
TL;DR: This locus is indeed novel, indicating the least usage of exon sequences in specifying different transferase isozymes that have an expansive substrate range.