Showing papers on "Dibutyl phthalate published in 1977"
TL;DR: Investigations using n -butanol, o -phthalic acid, and monobutyl phthalate, the major metabolite of DBP, showed that testicular effects were reproducible by MBP, andoadministration of zinc was found to afford a substantial measure of protection against testicular damage produced by DBP.
107 citations
TL;DR: Saccharomyces cerevisiae strain XV185-14C for reversion studies was used to investigate the genetic activity of alpha-benzene hexachloride dibutyl phthalate and trichloroethylene, which appears to be a powerful mutagen.
Abstract: Saccharomyces cerevisiae strain XV185-14C for reversion studies was used to investigate the genetic activity of α-benzene hexachloride dibutyl phthalate and trichloroethylene. The results indicate that none of the three compounds was genetically active when yeast cells were treated in phosphate buffer (pH 7.0) in the absence of metabolic conversion. However, in the presence of the 9000 g supernatant of mice liver homogenate, NADP, glucose-6-phosphate, phosphate buffer (pH 7.4), MgCl 2 , KCl, the components which were used for the metabolic conversion, trichloroethylene proved to be a powerful mutagen. It increases the frequency of homoserine, histidine and lysine revertants over those of the control levels. Trichloroethylene appears to induce frameshift as well as base substitution mutations.
59 citations