Showing papers on "Epstein-Barr virus associated gastric carcinoma published in 2001"
TL;DR: The findings regarding location, histology and weak male predominance are different from what has been described in Asian and European countries, but similar to those described in Mexico and Mexican descendants living in the U.S. suggesting unique characteristics of EBV‐associated GC in Latin‐America.
Abstract: Epstein-Barr virus (EBV) has been associated with the most common form of stomach neoplasms, the gastric carcinoma (GC). The presence of EBV-encoded small RNAtype-1 (EBER-1), a marker for EBV infection was analyzed by in situ hybridization (ISH) in 185 formalin-fixed and paraffin-embedded cases of GC from a high risk region. We found 31 (16.8%) EBV-positive cases with no relationship to age. Although male predominance (19% in males and 12.5% in females) was observed, the gender difference did not achieve statistical significance. Odds ratio (OR) for cardia location was 5.4 (95% CI 1.7–17.3) when antrum was used as referent category and the effects of gender and age were taken into account. The proportion of EBV-positive cases in diffuse histology was higher than intestinal type (OR = 4.8, 95% CI = 2.0–11.1). Our findings are contrary to a previously accepted hypothesis, that high-risk countries for GC have low rates of EBV-associated GC. In addition, our findings regarding location, histology and weak male predominance are different from what has been described in Asian and European countries, but similar to those described in Mexico and Mexican descendants living in the U.S. suggesting unique characteristics of EBV-associated GC in Latin-America. © 2001 Wiley-Liss, Inc.
87 citations
TL;DR: Recent advances in molecular biological techniques have demonstrated that an unexpectedly wide variety of neoplasms in the general population is associated with EBV infection, among which EBV-associated gastric carcinoma (EBVaGC) is the most common with a worldwide distribution.
Abstract: Epstein-Barr virus (EBV) is the first virus that was identified in a human neoplastic cell in 1963 Epstein 1994) More than 90% of the world population is infected with EBV before adolescence, and it is thought that a small population develops EBV-associated malignancy in an endemic manner, such as Burkitt’s lymphoma in equatorial Africa Osato 1998) and nasopharyngeal carcinoma (NPC) in Southern China Raab-Traub 1992) However, recent advances in molecular biological techniques have demonstrated that an unexpectedly wide variety of neoplasms in the general population is associated with EBV infection (Anagnostopoulos and Hummel 1996), among which EBV-associated gastric carcinoma (EBVaGC) is the most common with a worldwide distribution In Japan, for example, more than 5,000 patients are estimated to develop gastric carcinoma annually in association with EBV (less than 10% of total gastric cancer) (Fukayama et al 1998)
31 citations
TL;DR: The results suggest that the presence ofDR11‐restricted cytotoxic T cells (CTLs) related to EBV‐associated gastric carcinoma, or a deficiency of DR11 and a high frequency of DQ3 may be genetic markers for a population at greater risk of EBV-associated gastrics carcinoma.
Abstract: To assess the association between specific types of human leukocyte antigen and the risk of Epstein-Barr virus (EBV)-associated gastric carcinoma, serological typing for major histocompatibility complex class I and class II antigens was performed for 110 EBV-positive and 155 EBV-negative gastric carcinoma cases. In class I analysis, the frequency of B59 in the EBV-positive cases was higher than for the EBV-negative cases (odds ratio (OR) 3.06; 95% confidence interval (CI) 1.02-9.23). For class II antigens, DQ3 and DR9 frequencies in the EBV-positive cases were higher (OR 1.94; 95% CI 1.16-3.24 and OR 1.93; 95% CI 1.11-3.37, respectively), whereas DR11 frequency was lower than found in the EBV-negative cases (OR 0.10; 95% CI 0.01-0.79). After adjusting for multiple comparisons, only DR11 frequency remained significantly lower in the EBV-positive cases (P = 0.04), and the association of DQ3 was marginally significant (P = 0.05). These results suggest that the presence of DR11-restricted cytotoxic T cells (CTLs) related to EBV-associated gastric carcinoma, or a deficiency of DR11 and a high frequency of DQ3 may be genetic markers for a population at greater risk of EBV-associated gastric carcinoma. However, further extensive studies to more cases and DNA typing are needed because our findings in this study are exploratory.
16 citations