Showing papers on "Fibrinoid necrosis published in 1970"
TL;DR: In this paper, morphologic and morphometric studies were carried out on pulmonary vessels in lung tissue from 156 patients, for whom a diagnosis of primary pulmonary hypertension had been made, for which the media is only slightly thicker than normal; in 31 of the 156 cases the vascular lesions corresponded to this pattern.
Abstract: Morphologic and morphometric studies were carried out on pulmonary vessels in lung tissue from 156 patients, for whom a diagnosis of primary pulmonary hypertension had been made. This material was collected from 51 medical centers. Chronic pulmonary thromboembolism can be recognized by organizing thrombi, patchy intimal fibrosis, and intra-arterial septa. The media is only slightly thicker than normal; in 31 of the 156 cases the vascular lesions corresponded to this pattern. Other conditions such as chronic pulmonary venous hypertension, pulmonary veno-occlusive disease, sarcoidosis, chronic bronchitis, and pulmonary schistosomiasis could also be classified from the morphologic criteria. The largest group comprised 110 cases showing medial hypertrophy, laminar intimal fibrosis, and often fibrinoid necrosis, arteritis, and plexiform lesions. These alterations suggest that they were initiated by vasoconstriction. In children the sex ratio is equal; in adults there are almost four females to one male. In the...
500 citations
TL;DR: It is felt that the reported case of the hypersensitivity angiitis of the type involving the small arterioles especially of the lung, spleen, and kidney was secondary to the administration of allopurinol, a xanthine oxidase inhibitor currently used in the treatment of disorders of uric acid metabolism.
71 citations
TL;DR: Morphologic similarities to canine cutaneous mast-cell tumors, cutaneous lesions of collagen diseases, and calcinosis circumscripta are noted and the possibility of relationships to these lesions is discussed.
Abstract: A description of equine cutaneous mastocytosis is given. The lesion was characterized by focal aggregates of mast cells, and by eosinophils, fibrinoid necrosis of collagen, and focal necrosis with ...
34 citations
TL;DR: Four women are presented who, after uneventful pregnancy and delivery, developed hypertension and renal failure accompanied by hemolytic anemia and thrombocytopenia, and all patients died in uremia and at autopsy showed fibrinoid necrosis andThrombosis of renal arterioles and thROMbosis and thickening of glomerular capillaries.
28 citations
TL;DR: The clinical manifestations observed are correlated with vascular lesions in the hypothalamus and pons attributable to systematic lupus erythematosus, and both supraoptic and paraventricular hypothalamic nuclei exhibited gliosis, acute neuronal degeneration and a paucity of neurosecretory cells.
21 citations
TL;DR: Whether the structural and morphological diversity of the vascular lesions was apt to etiologically differentiate the disease as suggested by Vazquez et a1.3~, 3s and Winsor,4° or it simply represented different stages of vascular damage encountered at various times of examination is clarified.
Abstract: Previous studies 14, 16, 20, 21, 33, 34 have shown that under diverse conditions of experiment the fibrinoid necrosis of the vessel wall developed by an identical mechanism and also the microscopic appearance of the lesions was essentially similar, differing only in their degree depending on the time of examination as well as on the duration and intensity of the etiological factor. With these facts in mind, further studies have been carried out in this laboratory to clarify, whether the structural and morphological diversity of the vascular lesions was apt to etiologically differentiate the disease as suggested by Vazquez et a1.3~, 3s and Winsor,4° or it simply represented different stages of vascular damage encountered at various times of examination.
4 citations