Showing papers in "The American Journal of Medicine in 1970"

TL;DR: The largest group comprised 110 cases showing medial hypertrophy, laminar intimal fibrosis, and often fibrinoid necrosis, arteritis, and plexiform lesions, suggesting that they were initiated by vasoconstriction.

TL;DR: The arteriographic findings, including the absence of a cortical nephrogram and unrecognizable renal cortical vasculature in the patients with the most severe degree of renal failure, support the concept of a reduction in renal cortical perfusion.

TL;DR: Lipids are classified into soluble and insoluble species and it is suggested, as far as is presently possible, how soluble lipids form mixed micelles with insoluble lipids.

TL;DR: Skeletal tuberculosis occurs in approximately 1 per cent of patients with tuberculosis and early diagnosis is essential since excellent therapy is available and far advanced destruction and long suffering and disability can be avoided.

TL;DR: Hepatic fibrosis probably stimulated by hepatocellular injury may, in turn, damage the hepatic parenchyma, and this may be more important in the self-perpetuation of liver injury than the immunologic components of hepatic inflammation.

TL;DR: It is proposed that neuroendocrine cells migrate into the primitive allimentary tract mucosa and are carried with the developing endocrine glands to their final resting places, where they mature into endocrine cells of the anterior pituitary, thyroid, parathyroid, islets of Langerhand, ultimobranchial body and thymus.

TL;DR: A bimodal distribution in the age-specific incidence of polymyositis suggests to us that the polymyposis that occurs in childhood may be of different pathogenesis or immediate precipitation than the disease that has its onset in adulthood.

TL;DR: In this paper, the Henderson-Hasselbalch equation was used to calculate the bicarbonate concentration of each fluid and correlate the changes in bicrate with the increases in lactate.

TL;DR: An overload of the liver cell with numerous lipid- soluble drugs increases drug metabolizing enzymes in the endoplasmic reticulum and augments the smooth membranes in the hepatocytes with the results that all lipid-soluble compounds reacting with cytochrome-P450 are oxidized more rapidly.

TL;DR: Four cases that support the concept of a limited form of Wegener's granulomatosis are described, and pathologic and pulmonary findings represent a variant of classic Wegener’s granumatosis, lacking the renal involvement that occurs with the latter.

TL;DR: The Australia antigen is a particle of about 200 A with the appearance of a virus and can be detected in the nuclei of liver cells of patients with hepatitis using fluorescent antibody technics.

TL;DR: In this article, the effects of acute ethanol intoxication on drug metabolism were studied in man and rats, and it was shown that ethanol ingestion significantly retarded the disappearance of pentobarbital and meprobamate from the blood in human volunteer subjects and rats.

TL;DR: The main topics are: Effect of oral contraceptives on the liver, the mechanism of the cholestatic effect of steroids, possible genetical defects involved and the likely connection between the metabolism of hormonal steroids and the formation of gallstones in women.

TL;DR: GSA levels and the degree of inhibitio of ADP-induced PF-3 activation decreased in parallel in the serum and plasma of uremic patients undergoing peritoneal dialysis, and can account for a number of the in vitro abnormalities of Uremic platelet function and may be partly responsible for the bleeding syndrome of u Remia.

TL;DR: The effects of heatstroke on the structure and function of the liver have been studied in Bantu gold miners and it is suggested that the hepatic changes are the result of a combination of hypoxia and direct thermal injury.

TL;DR: Normal gastrointestinal histologic appearance was found in all instances and permitted the differentiation of idiopathic intestinal pseudo-obstruction as an entity distinct from scleroderma, suggesting a functional failure of the myenteric plexus.

TL;DR: It is concluded that useful conclusions can be derived only by comparative studies using either different poisons or animals in differing physiologic states.

TL;DR: Migration of polymorphonuclear leukocytes toward a chemotactic source was the only leukocytic activity affected by colchicine concentrations in the range of those found in the plasma of these patients.

TL;DR: Two siblings were found to be affected by an oculorenal syndrome consisting of familial nephropathy and retinitis pigmentosa, and in addition two other extrarenal manifestations, cerebellar ataxia and skeletal abnormalities, not previously reported, were demonstrated in both patients.

TL;DR: It is still uncertain whether portal pressure is useful in predicting variceal bleeding, but two groups of investigators have recently shown that wedged hepatic vein pressure and portal vein pressure are essentially identical in alcoholic liver disease and probably in cryptogenic cirrhosis and chronic active hepatitis.

TL;DR: Mithramycin, an inhibitor of the synthesis of ribonucleic acid (RNA), was administered to fifty-eight patients with a variety of advanced carcinomas, and striking objective improvement occurred in embryonal cell cancer of the testis.

TL;DR: Current diagnostic criteria for Gilbert's syndrome, which exclude patients with hemolysis, will result in an artificial distinction among patients with the same basic hepatic abnormality, according to Multicompartmental analysis.

TL;DR: In this paper, aortic stenosis was found to be associated with acute rheumatic fever (ARF) or chorea in 139 patients with valvular cardiac disease.

TL;DR: Analysis of data from eighty-six patients with active chronic hepatitis who have been followed for up to nineteen years together with a comprehensive survey of the literature forms the basis for this review of the natural history of this disease.

TL;DR: A heterogeneous collection of organisms, poorly described in the past, have been grouped together operationally in the laboratory, based on their nonfermentative character, and the striking frequency with which respirator equipment was associated with the isolation of these organisms from the sputum suggests that such equipment may be one reservoir.

TL;DR: Of 530 patients with a diagnosis of active histoplasmosis, twenty-five had progressive disseminated disease and the efficacy of treatment with amphotericin B is attested to by the fact that mortality in the untreated group was 100% and in the adequately treated group only 7 per cent.

TL;DR: According to autopsy, this infant could not adequately metabolize B, and as a result failed to accumulate coenzymatically-active derivatives of vitamin B, in normal amounts, and it is suggested that therapeutic benefit may derive from the administration of forms of 6, that could circumvent the metabolic block, by giving substances that could stimulate the non-B, -dependent methionine-synthesizing system or by the Administration of methamphetamineionine in large doses.