Showing papers on "Genomics published in 1995"

Caenorhabditis elegans : modern biological analysis of an organism

Abstract: Genetic and culture methods neurobiology cell biology and molecular biology genomics and informatics appendices - additional information and resources, Caenorhabditis genetics centre (laboratory designations), gene names and descriptions.

Genetic dissection of inflammatory responses.

Abstract: Recent advances in classical genetics, molecular biology, and genomics herald a renaissance of genetic analysis of hereditary disease in both humans and animal models. It is increasingly feasible to analyze multifactorial traits both genetically and functionally. These advances parallel research aimed at unravelling the genetic code of humans and model species. Only the integration of these two approaches will secure the functionally significant conclusion of the genomic exercise.

USDA Plant Genome Research Program

Abstract: The U.S. Congress appropriated funds in 1991 for the USDA Plant Genome Research Program, four years after its initial conception in 1987. The goal of the USDA Plant Genome Research Program is to improve plants (agronomic, horticultural, and forest tree species) by locating marker DNA or genes on chromosomes, determining gene structure, and transferring genes to improve plant performance with accompanying reduced environmental impact to meet marketplace needs and niches. The Plant Genome Research Program is one program with two parts: National Research Initiative and Plant Genome Database (PGD). The PGD is now a real and functioning information and data resource for agricultural and other plant science genome researchers, and it is in the public domain. Additional progress is given according to major plant groups. The PGD is a suite of several information products produced at the National Agricultural Library (NAL) in collaboration with the Agricultural Research Service and Forest Service species coordinators.

The functional analysis of the human genome

Abstract: Structure and function in the human genome, D.N. Cooper Mapping the human genome, D.N. Cooper Cloning the transcribed portion of the genome, P. Towner Retroviral insertional mutagenesis, F. Farzaneh et al Gene entrapment, H. von Melchner and H.E. Rule

Engineering in genomics. Technical improvements in high throughput genome sequencing

Abstract: High-throughput DNA sequencing of the C. elegans genome currently is ongoing at our Genome Sequencing Center (GSC) at Washington University School of Medicine in St. Louis and at the Sanger Centre in Hinxton, England. Our collaborative effort is aimed at completion of this 100 Mb genome by the end of 1998. Now just into our fifth year of sequencing, we have amassed a combined output of over 22 Mb of completed sequence. The first two years of the pilot project were spent investigating and evaluating different approaches to genome sequencing with respect to throughput, ease of associated techniques, and methods and their robustness. The resulting approach has since been used to produce almost all of the genome sequencing data for C. elegans and will, with appropriate modifications, continue to be our strategy of choice for the completion of this genome sequence and the beginning of the human genome. The basic strategy consists of three phases: a library construction phase, a production sequencing ("shotgun") phase, and a directed "finishing" phase. >

Genome mappers have a hot time at Cold Spring Harbor

Abstract: This is a report on the Genome Mapping and Sequencing meeting from 10-14 May 1995. Debate included how to start the final stage of the Human Genome Project (HGP) - large scale sequencing and the problem of funding. Major accomplishments of the HGP are summarized briefly including: maps of at least two chromosomes, 16 and 19, are in the final difficult stage and will be the first to be completely sequenced; evidence is being refined on the myotonic dystrophy gen; and an attempt to fashion a silicon chip to detect specific DNA sequences.