Showing papers on "Granulopoiesis published in 1970"
TL;DR: The findings suggested that neutropenia increases the rate of release of segmented neutrophils from the marrow and also increases the rates of production of neutrophil precursors, possibly by increasing the rateof flux from a committed granulocytic stem cell compartment into the myeloblast-promyelocyte compartment.
43 citations
30 citations
21 citations
TL;DR: Six days after unilateral ureteral ligation, serum colony-stimulating factor (CSF) is four times as high as in nonoperative germfree mice, supporting the view that CSF not only is capable of stimulating proliferation of granulocytes and mononuclear cells in vitro, but also promotes granulopoiesis in vivo.
Abstract: SummarySix days after unilateral ureteral ligation, serum colony-stimulating factor (CSF) is four times as high as in nonoperative germfree mice. The elevation in serum CSF is associated with a significant increase in peripheral blood granulocytes, but not lymphocytes, monocytes, or eosinophils. This finding supports the view that CSF not only is capable of stimulating proliferation of granulocytes and mononuclear cells in vitro, but also promotes granulopoiesis in vivo, and can be regarded as a leukopoietin.
6 citations
Journal Article•
3 citations
TL;DR: The short-term cycle appears to be an oscillatory feature of normal granulopoiesis, whereas the long-term cyclic fluctuation may denote abnormality of granulipoiedis.
Abstract: A short-term cyclic fluctuation (14 to 24 days) of the neutrophil count in normal adults was shown by MORLEY [Lancet ii: 1220, 1966]. In contrast, a longer duration cyclic fluctuation (30 to 120 days) was seen by MORLEY, BAIKEIE and GALTON in 4 patients with chronic granulocytic leukemia [Lancet ii: 1320, 1967]. We have observed similar long-term cycles in 8 children during remission of acute leukemia (myeloblastic or monomyelogenous) in the absence of infections or changes of any chemotherapeutic agents. Likewise, a child with trisomic Down's syndrome and an unusual aplastic anemia showed long-term cycles for 18 months prior to his demisc. A prospective study of neutrophil cycles in 6 prepuberal males was undertaken under controlled conditions for 3 ½ months. Results of this study are as follows: Graphic display of neutrophil counts done twice weekly in 3 nonmongoloid controls shows only short-term cycles. However, the 3 patients with trisomy 21 reveal long-term cycles as well, upon which the short-term cycles are superimposed. The short-term cycle appears to be an oscillatory feature of normal granulopoiesis, whereas the long-term cycle may denote abnormality of granulopoiesis.
2 citations
TL;DR: During the past fifteen years important information has evolved from a number of laboratories on the kinetics of granulopoiesis in normal and diseased states but evaluation of regulatory mechanisms has been hampered by the lack of an adequate assay system such as 59Fe labeling of the erythroid series for evaluation of erythropoietin.
Abstract: During the past fifteen years important information has evolved from a number of laboratories on the kinetics of granulopoiesis in normal and diseased states. Evaluation of regulatory mechanisms, however, has been hampered by the lack of an adequate assay system such as 59Fe labeling of the erythroid series for evaluation of erythropoietin. Thus, we have been in the frustrating position of being able to describe the production and destruction rates of granulocytes but unable to approach the key question adequately: What regulates granulocyte production? The only simple measure of granulopoiesis has been the numbers of granulocytes produced after perturbation. Granulopoiesis . . .