Showing papers on "Hypersensitivity reaction published in 1978"

A comparative study of prevalence of skin hypersensitivity to cockroach and house dust antigens.

Abstract: Allergy skin tests with cockroach antigen along with various common inhalant allergens were performed on 222 atopic and on 63 non-atopic subjects. The most prevalent allergen producing a positive skin test was house dust antigen with a positive response of 72%, 78% and 57% in atopic adults, atopic children and non-atopic children, respectively. The next prevalent positive skin test was to cockroach antigen with 50%, 60% and 27%, respectively, of the three groups tested. The differences between positive cockroach hypersensitivity and house dust hypersensitivity in all three groups tested were statistically significant. Next in order of prevalence of positive skin test to common inhalants were western weeds, ragweeds and cats. Incidence of cockroach hypersensitivity was 58% among asthmatic adults and 69% among asthmatic children. The results indicate that cockroach hypersensitivity is highly prevalent and that cockroach antigen is an independent agent from house dust as a cause of immediate hypersensitivity reaction.

Hypersensitivity Reactions in the Small Intestine

Abstract: The effect of a local delayed hypersensitivity reaction (allograft rejection) on small intestinal architecture has been examined by using scanning electron microscopy of the mucosal surface. In isogra

Azulfidine- (sulfasalazine-) induced hepatic injury.

Abstract: A patient with Azulfidine-related hepatotoxicity in which prompt recurrence of symptoms, fever, skin rash, and laboratory evidence of hepatocellular injury occurred upon readministration of Azulfidine is reported. The clinical and biochemical features support the fact that this was an example of an acquired hypersensitivity reaction to Azulfidine.

TRUE ANAPHYLAXIS TO SUXAMETHONIUM CHLORIDE A case report

Abstract: A severe anaphylactic reaction to suxamethonium chloride is reported. The patient had received suxamethonium uneventfully on four previous occasions. Previous sensitization and immunological studies indicated that this was a classical type I hypersensitivity reaction.

Hepatic Injury in a Child Caused by Trimethoprim-Sulfamethoxazole

Abstract: Trimethoprim-sulfamethoxazole was given to a 16-year-old boy as prophylaxis for a urinary tract infection. He developed severe cholestatic hepatitis 41 days after administration of the drug. A liver biopsy specimen showed a mixed inflammatory infiltrate in the portal triads and prominent bile stasis. The clinical course in this patient supports the concept of an indirect hypersensitivity reaction to sulfamethoxazole.

Allopurinol-Induced Arteritis in Partial HGPRTase Deficiency: Atypical Seizure Manifestation

Abstract: A 17-year-old boy with partial hypoxanthine-guanine phosphoribosyl transferase deficiency developed a hypersensitivity reaction to allopurinol. The reaction was manifested by the development of bizarre, atypical seizures. The patient had been neurologically normal prior to the reaction. Seizures disappeared following discontinuation of allopurinol therapy. Allopurinol apparently can cause a diffuse vasculitis involving cerebral vessels after many years of therapy, resulting in atypical seizures. ( Arch Intern Med 138:1743-1744, 1978)

Hypersensitivity reaction to allopurinol

Abstract: Major hypersensitivity reactions to allopurinol are rare. They are characterized by systemic vasculitis associated with a grave clinical picture. 20 days after beginning treatment with allopurinol, a 70-year-old patient presented with a maculo-papular, erythemato-squamous eruption which developed into erythroderma with fever, edema, polyadenopathy, marked eosinophilia, cholostatic jaudice, and aggravation of preexisting renal insufficiency. Skin biopsy showed vasculitis with fibrinoid necrosis and a chiefly lymphocytic infiltrate suggestive of a malignant lymphoma-type process. As soon as allopurinol was discontinued, and without steroid treatment, the patient spontaneously recovered. A lymphocyte transformation test was positive for this drug. The poorly know mechanism is immunological, with formation of immune complex deposits on the endothelial cells and at the dermo-epidermal junction, fibrinoid necrosis of small vessels and cellular reaction which is lymphocytic. It is not a toxic reaction related to the dose administered, though most authors have emphasized that preexisting renal insufficiency could favor hypersensitivity to allopurinol.

Febrile response to whirlpool bath treatments.

Abstract: To the Editor— I was surprised by the letter from Greenberg et al (238:1912, 1977) describing a patient experiencing a febrile response to whirlpool bath treatments Unable to document bacteremia, they suggested the possibility of a toxin or perhaps a transient bacteremia that was missed They apparently overlooked the povidone-iodine in the whirlpool water Harvey 1 describes a hypersensitivity reaction to moderate amounts of iodine applied to the skin Symptoms include fever, severe constitutional reaction, and generalized skin eruption It is possible that a burn patient would be more susceptible to the low concentrations of povidone-iodine present in whirlpool water, resulting in a transient febrile reaction

Unusual evidence of myocardial involvement during a hypersensitivity reaction to oral penicillin.

Abstract: A hypersensitivity reaction to orally administered phenoxymethyl penicillin is reported. The manifestations of the reaction included fever, arthralgia, urticaria and an irregular pulse. Serial ECG showed second-degree atrioventricular block with junctional escape beats, an atypical Wenckebach pattern and, finally, first-degree atrioventricular block with gradually decreasing PR intervals. A normal tracing was recorded on the sixth day despite the persistence of the rash and joint pains.

Cellular reaction to autologous tumor tissue followed by "skin window" technique in orofacial tumors.

Abstract: In a sample of patients with pseudotumors and benign and malignant tumors of the orofacial region there has repeatedly been investigated, after radical surgery, the cell reaction to autologous tumor tissue applied at indicated time intervals on a small skin lesion. The prognostically favorable picture of a cellular-type hypersensitivity reaction with massive participation of lymphoid cells and basophil granulocytes was only found in some basaliomas and leukoplakias. Conversely, spinocellular carcinomas are, irrespective of localization, characterized by areactivity.

[Biochemical and pharmacological properties of new 2-substituted aziridines. Contribution to experimental tumor research].

Abstract: A new class of compounds, the 2-cyanaziridines, has immune-modulating properties. This immune-modulation was proved by the influence on the delayed type hypersensitivity reaction, the increase of the lymphocyte transformation by T-cell-specific mitogens ConA and PHA, the increase of phagocytosis of macrophages, the increase of resistance against bacterial, fungal and virus infections and by the influence on various transplantation tumors in mice and rats.

[Clometacine hepatitis. 2 cases (author's transl)].

Abstract: Two women (aged 72 and 78 years) developed hepatitis due to clometacine. The main laboratory abnormalities were raised transaminases and blood eosinophil count. In one of these cases, in which the initial histological lesions had the appearance of aggressive chronic hepatitis, there was progression to cirrhosis despite the interruption of treatment. The mechanism of this hepatotoxicity is probably a hypersensitivity reaction.