Showing papers on "Interstitial lung disease published in 1976"
TL;DR: In the present series, the patients with mixed alveolar and interstitial infiltrates on chest radiograph and organizing pneumonia and bronchiolitis obliterans in addition to interstitial pneumonitis are treated.
188 citations
75 citations
TL;DR: Avoidance of the contaminated system, and the use of corticosteroids in more severe cases, seems to be appropriate therapy for patients with this disease.
Abstract: Eight patients had hypersensitivity pneumonitis due to contaminated home or office forced-air heating or air-conditioning systems. We studied their clinical and laboratory features, and the results indicated that this disease may occur as an acute or insidious form differing in type and intensity of respiratory and systemic symptoms. Thermophilic actinomycetes contaminatinf the forced air systems were identified as the sensitizing agents in most cases. Precipitating antibodies to the organisms could be shown in the serums of the patients and the antigen identified by immunofluorescent studies in the three lung biopsies examined by this method. Inhalation challenge studies with the cultured organism or other materials obtained from the forced air systems reproduced the clinical syndrome in the four patients tested. Avoidance of the contaminated system, and the use of corticosteroids in more severe cases,seems to be appropriate therapy for patients with this disease.
65 citations
TL;DR: The findings suggest that in some cases desquamative interstitial pneumonia may be drug related, and treatment consisted of discontinuing the administration of nitro=furantoin and adding corticosteroids.
55 citations
TL;DR: The value of gallium lung scan was investigated to assess its ability to predict inflammatory activity in such a clinical setting and found it to be insensitive to subtle changes that can occur in minimally active disease with slowly progressive interstitial pulmonary fibrosis over a period of years.
49 citations
TL;DR: The degree of fibrosis appeared more closely related to functional changes than either interstitial mononuclear cell infiltration or vessel wall enlargement; the fibrosis grade showed coefficients of correlation of 0.50 with resting PaO,, 0.45 with vital capacity, 0.38 with the exercise PaO, and 0.36 with the total lung capacity.
18 citations
Journal Article•
8 citations
TL;DR: Since the evidence for physiologic improvement with steroid therapy has been quite contradictory, several questions must be raised about the ability to assess changes to therapy in diffuse interstitial disease.
5 citations
2 citations
Journal Article•
TL;DR: In diffuse interstitial lung disease only open lung biopsy provides sufficient material for histological examination and the indication must be established restrictively: before biopsy it is essential to rule out all systemic diseases which may also produce interstitial Lung disease.
Abstract: The techniques for lung biopsy are briefly described. In diffuse interstitial lung disease only open lung biopsy provides sufficient material for histological examination. In view of the severity of this diagnostic intervention the indication must be established restrictively: before biopsy it is essential to rule out all systemic diseases which may also produce interstitial lung disease. Furthermore, open lung biopsy should be considered only if a therapeutic prospect exists.
1 citations