Showing papers on "Isoflavones published in 1975"
TL;DR: Among these isoflavones, IV and III showed the strongest activity in inhibiting dopa decarboxylase and catechol-O-methyltrasnferase.
Abstract: By screening of culture filtrates of fungi and streptomyces for activity in inhibit dopa decarboxylase the following isoflavone compounds were obtained: psi-tectorigenen (I), genistein (II), orobol (IV), 8-hydroxygenistein (V) and a new compound (III). III was elucidated to be 3', 4', 5, 7-tetrahydroxy-8methoxy isoflavone. Among these isoflavones, IV and III showed the strongest activity in inhibiting dopa decarboxylase. All these isoflavones also inhibited histidine decarboxylase and catechol-O-methyltrasnferase. Activities of these compounds to inhibit tyrosine hydroxylase and dopamine beta-hydroxylase were examined. Orobol which showed no or only slight inhibition of tyrosine hydroxylase and dopamine beta-hydroxylase exhibited a significant hypotensive effect on spontaneously hypertensive rats.
44 citations
TL;DR: Three new isoflavones were isolated from streptomyces culture filtrates and I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action.
Abstract: In the screening of catechol-O-methyltransferase inhibitors in streptomyces culture filtrates, three new isoflavones were isolated. Their structures were shown to be 3',5,7-trihydroxy-4',6-dimethoxyisoflavone (I), 3',5,7-trihydroxy-4',8-dimethoxyisoflavone (II), 3',8-dihydroxy-4',6,7-trimethoxyisoflavone (III). I and II inhibited both catechol-O-methyltransferase and dopa decarboxylase, and showed hypotensive action. III was a specific inhibitor of catechol-O-methyltransferase, and showed no hypotensive action.
22 citations
21 citations
TL;DR: The structure of 7,4′-dihydroxy-6-methoxyisoflavone (glycetein) was confirmed by synthesis and the heartwood of Mildbraedeodendron excelsa has yielded five isoflavones and an ( ± )-isoflavanone.
9 citations
TL;DR: Condensation of cyanomethyl derivatives of benzimidazole and benzothiazole with resorcinol gave the corresponding 2,4-dihydroxy-α-hetarylacetophenones as mentioned in this paper.
Abstract: Condensation of cyanomethyl derivatives of benzimidazole and benzothiazole with resorcinol gave the corresponding 2,4-dihydroxy-α-hetarylacetophenones. The latter were converted to 3-hetarylchromones with methyl, trifluoromethyl, and ethoxycarbonyl groups in the 2 position or to chromones without substituents in this position.
3 citations
TL;DR: In this paper, the authors synthesized thiazole analogs of natural isoflavones, and their reactions with alkalis, phosphorus pentasulfide, and alkylating and acylating agents were studied.
Abstract: Thiazole analogs of natural isoflavones were synthesized, and their reactions with alkalis, phosphorus pentasulfide, and alkylating and acylating agents were studied. Data on the biological activity of the compounds are presented.
1 citations
1 citations