Showing papers on "Isopimpinellin published in 2009"
TL;DR: The results strongly suggest that imperatorin and auraptene induce murine liver cytosolic GST activities via the Nrf2/ARE mechanism and suggest that isopimpinellin may induce GST and NQO1 via additional mechanisms.
63 citations
Journal Article•
TL;DR: In this article, a new coumarin diol has been isolated along with three known compounds, 6,8-diprenylumbelliferone, bergapten and isopimpinellin from the chloroform fraction of the leaves of the plant, Chloroxylon swietenia DC.
Abstract: A new coumarin diol has been isolated along with three known coumarin compounds, 6,8-diprenylumbelliferone, bergapten and isopimpinellin from the chloroform fraction of the leaves of the plant, Chloroxylon swietenia DC. The structure of new compound has been established as 6-(2',3'-dihydroxy-3-methylbutyl)-8-prenylumbelliferone based on the spectral (UV, IR, 1 H, 13 C and 2D NMR and mass) data.
11 citations
Journal Article•
TL;DR: In this article, the structures of these compounds were elucidated by UV, IR, 1D and 2D NMR techniques and different fractions from the leaves of C. swietenia were investigated for their tyrosinase inhibition activity.
Abstract: From the leaves of Chloroxylon swietenia DC., 5 known secondary metabolites, namely 6, 8-diprenylumbelliferone (1), bergaptan (2), isopimpinellin (3), tritriacontanol (4), and isoquercetrin (5), were isolated from a folklore medicinal plant. Three compounds were isolated for the first time from this genus. The structures of these compounds were elucidated by UV, IR, 1D and 2D NMR techniques. Different fractions from the leaves of C. swietenia were investigated for their tyrosinase inhibition activity.
11 citations
TL;DR: In this paper, a method of supercritical fluid extraction of the main furocoumarins (bergapten, xanthotoxin, and isopimpinellin, compounds used as photosensitizers in PUVA therapy) from seeds of apiaceous plant Ammi Majus was developed.
Abstract: A method of supercritical fluid extraction of the main furocoumarins (bergapten, xanthotoxin, and isopimpinellin, compounds used as photosensitizers in PUVA therapy) from seeds of apiaceous plant Ammi Majus was developed. A technique for analyzing the composition of extracts and for isolating individual furocoumarins with the help of supercritical fluid chromatography was proposed.
10 citations
Journal Article•
TL;DR: In this article, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7 O-rutinoside, and 6-hydroxapigenin this article were isolated from the methanol extract of Malabaila suaveolens Coss.
Abstract: Volatile oil components, fatty acids, β-amyrin, and sterols were identified in the n -hexane extract of Malabaila suaveolens Coss. fruits. Angelicin, 4,7,9-trimethyl psoralen, isopimpinellin and umbelliferone were isolated from the dichloromethane extract of the plant. 5-Hydroxy 7, 3`, 4`-trimethoxyflavone, apigenin and its 7-O0-β-D-glucopyranoside were isolated from the ethyl acetate extract. From the methanol extract, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7-O-rutinoside, and 6-hydroxyapigenin 7-O-β-D-glucopyranoside were isolated. Toxicity study of n-hexane, dichloromethane, ethyl acetate extract and methanolic extracts of the plant proved that it is relatively nontoxic. The tested extracts showed significant analgesic and anti-inflammatory effects as compared with control groups and reference drugs. Also, the tested extracts showed significant antioxidant activity as compared with reference.
5 citations
Dissertation•
20 May 2009
TL;DR: This study showed that the lowest ECOD activity was detected in humans and there was no similarity between other species.
Abstract: Cytochrome P450 enzymes (CYP) are hemoproteins belonging to the group of monooxygenases and one of the main enzymatic systems responsible for drug metabolism. In the present study, in vitro approach was applied to evaluate the relation of CYP-catalyzed activities between human, rabbit, minipig and mouse, using single substrate assays (MultiCYP 7-ethoxycoumarin 0-deethylase (ECOD), CYP1A1/2 7-ethoxyresorufin 0deethylase (EROD), CYP2A6 coumarin 7-hydroxylase (COH), CYP3A4 midazolam 1hydroxylase (OH-MDZ), and CYP2E1 chlorzoxazone 6-hydroxylase (OH-CLZ)). It was also studied plant extracts (Pinus sylvestris, Angelica archangelica, Mentha sp., Citrus grandis) and phytochemicals (8-Hydroxybergapten, 5,6-dihydroxyangelicin, α, β-Thujone, α-Thujone, angelicin, bergamottin, bergapten, bergaptol, cnidilin, imperatorin, isobergapten, isopimpinellin, lanatin, phellopterin, psoralen, sphondin, xanthotoxin) as potential inhibitors in CYP-related activities of hepatic human microsomes (CYP1A1/2 (EROD), CYP2A6 (COH), CYP3A4 (OH-MDZ)). This study showed that the lowest ECOD activity was detected in humans and there was no similarity between other species. CYP1A1/2 showed equivalent activities. The highest CYP activities in humans were found for CYP2A6 and CYP3A4. In CYP2E1 activity, two similar groups were recognized: human and mouse versus rabbit and minipig. EROD reaction was the most inhibited CYP-mediated reaction. COH reaction was inhibited by few compounds. The highest inhibition was detected among angular furocoumarins. Linear furocoumarins group had the lower inhibitory concentration of CYP3A4. Thujone showed weak inhibition of CYP activities.