Showing papers on "Mass action law published in 1994"
TL;DR: In this article, a thermodynamic treatment of equilibria of protolytic reaction involving ligands immobilized at a rigid matrix surface is put forward, and a shift observed in equilibrium constants of such reactions related to analogous reactions of free ligands is qualitatively explained.
15 citations
TL;DR: In this article, the reliability and limits of the ideal mass action law formalism to describe thermodynamic and electrical properties of nonstoichiometric compounds in the case where Coulomb interactions between defects are predominant are investigated.
5 citations
TL;DR: A simple method of numerical integration is adapted to predict the equilibrium state of a population of components undergoing reversible association according to the Law of Mass Action to populations of protein molecules in aqueous solution.
Abstract: We have adapted a simple method of numerical integration to predict the equilibrium state of a population of components undergoing reversible association according to the Law of Mass Action. Its particular application is to populations of protein molecules in aqueous solution. The method is based on Euler integration but employs an adaptive step size: the time increment being reduced if it would make the concentration of any component negative and increased while the concentration of any component changes at greater than a specified rate. Parameters of the algorithm have been optimized empirically using a model set of binding equilibria with dissociation constants ranging from 10(-5) M to 10(-9) M. The method obtains the solution to a set of binding equilibria more rapidly than the conventional initial value methods (simple Euler, 4th order Runge-Kutta and variable-step Runge-Kutta methods were tested) for the same accuracy. A computer code in standard C is presented.
3 citations