Showing papers on "Meth- published in 1985"

Treatment regimen and host T-cell-dependent therapeutic effect of interferon in mouse solid tumors.

Abstract: A highly purified hybrid human interferon (IFN)-α A/D, was used to define optimum treatment regimens for Meth A fibrosarcoma intradermally inoculated in syngeneic BALB/c mice. Treatments from the sixth day post-tumor inoculation were most effective, and 10 consecutive injections of IFN completely suppressed the tumor growth for a prolonged time without recurrence after the last injection of IFN. Intraperitoneal and intravenous injections were similarly effective. The therapeutic effect of IFN was abrogated by the injection of rabbit α-mouse thymocyte globulin but not normal rabbit globulin. The therapeutic effect of IFN was much poorer in BALB/c nu/nu mice, which are athymic and defective in T-cell immunity, than in BALB/c +/+ mice. Mice in which Meth A growth was completely suppressed by IFN were refractory to Meth A, but not Meth 1 tumor, another antigenically distinct fibrosarcoma, whereas mice in which Meth 1 growth was suppressed completely by IFN were refractory to Meth 1 but not Meth A tumor. These three findings suggest that the therapeutic effect of IFN depended on host T-cell immunity and that tumors were eventually eliminated by tumor-selective antitumor immunity provoked during IFN therapy. Under the present experimental conditions, the direct anticellular activity of IFN was presumed to contribute very little to the therapy for solid tumors, since the therapeutic effect of IFN on three different solid tumors was not correlated with their in vitro sensitivity to this substance: Colon 26, which was as sensitive to IFN as Meth A in the in vitro antiproliferation, responded most poorly to IFN therapy, while Meth A and Meth 1 responded similarly well to IFN therapy, although there was more than a 2500 times difference in their in vitro IFN sensitivity.

Effect of chronic methadone administration on neuroendocrine function in young adult rats.

Abstract: This study reports the endocrine effects of chronic methadone (METH) administration. Two treatment regimens were tested: a constant (5 mg/kg/day, CD) or increasing dose (5 mg/kg twice daily, increasing 1 mg/kg/day, ID). Basal hormone levels and endocrine responses to opiate challenge were determined on days 5, 10 and 20 and after withdrawal. METH effects on hormone secretion varied with treatment duration, dose and hormone. Tolerance to METH effects on corticosterone (CS), prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) developed during the ID regimen and basal CS, TSH and LH levels were altered. In addition, serum testosterone, T3 and T4 decreased significantly during this regimen. In contrast, only CS secretion was affected markedly by the CD regimen. Resting levels were elevated by day 5 and the CS response to acute METH challenge was reversed. Tolerance also developed to METH-induced TSH suppression, but only with longer treatment. Similarly, basal TSH and LH levels were affected only with longer treatment. Basal PRL, GH and LH levels and LH, PRL and GH responses to acute METH challenge were not affected by the CD regimen. Changes in basal CS and TSH levels observed in these studies probably reflect abstinence, as even more pronounced changes occurred after naloxone-precipitated abstinence and suppressed rather than reversed responses were observed if animals were withdrawn for 36 hr before testing. Tolerance in some endocrine systems appears to be quite long-lasting, as CS, TSH and PRL responses to METH challenge were still decreased 3 weeks after withdrawal from the ID regimen.(ABSTRACT TRUNCATED AT 250 WORDS)

Composition for repairing leakage of water

Abstract: PURPOSE: To titled composition suitable for preventing leakage of water of sewer without forming released water and striking swelling by water, containing a (meth)acrylate, polyethylene glycol di(meth) acrylate and a polymerization catalyst. CONSTITUTION: The aimed composition containing (A) a (meth)acrylate(preferably Mg salt or Na salt), (B) polyethylene glycol di(meth)acrylate [preferably water-soluble polyethylene glycol (meth)acrylate which may contain 20W30wt% mono(meth)acrylate] and (C) a polymerization catalyst (preferably combination of oxidizing agent and reducing agent). COPYRIGHT: (C)1987,JPO&Japio

Urethane (meth)acrylate compounds

Abstract: A novel urethane (meth)acrylate compound represented by a general formula shown below. ##STR1##

2,3,5,6-Tetrafluorophenyl (meth) acrylates and method for production thereof

Abstract: 2,3,5,6-Tetrafluorophenyl (meth)acrylates represented by the general formula I: ##STR1## wherein R is H or CH3 and X is H or CN are disclosed. These compounds are obtained by the reaction of 4-cyano-substituted or unsubstituted 2,3,5,6-tetrafluorophenols with (meth)acrylic acid chloride.

Methacrylic resin having improved solvent resistance

Abstract: PURPOSE:To obtain a methacrylic resin having improved solvent resistance, by copolymerizing methyl methacrylate with a (meth)acrylamide monomer. CONSTITUTION:Methyl methacrylate is copolymerized with 0.1-50wt% (meth) acrylamide shown by the formula (R1 is H, or methyl; X is H, methyl containing <=4C saturated alkoxy as a substituent group) such as (meth)acrylamide, N- methoxy-methyl(meth)acrylamide, N-propoxymethyl(meth)acrylamide, etc., to give the desired methacrylic resin.

2,3,5,6-tetrafluorophenyl (meth)acrylates and their production

Abstract: 2,3,5,6-tetrafluorophenyl (meth)acrylates represented by the general formula I: wherein R is H or CH3 and X is H or CN are prepared by the esterification of 4-cyano-substituted or unsubstituted 2,3,5,6-tetrafluorophenols with (meth)acrylic acid chloride.

Poly-n-(2-hydroxyethyl)-methacrylamide or acrylamide

Abstract: PURPOSE:The titled polymer having an affinity for blood and an anticoagulant property and useful as an anticoagulative, high-molecular surfactant or the like, obtained by polymerizing N-(2-hydroxyethyl)(meth)acrylamide. CONSTITUTION:N-(2-Hydroxyethyl)(meth)acrylamide is polymerized in, for example, the absence of a catalyst to obtain the purpose poly-N-(2-hydroxyethyl)(meth) acrylamide of the formula (wherein n>=10 and R is H or CH3). This polymer is novel one and shows an infrared absorption spectrum given in the table. N-(2- Hydroxyethyl(meth)acrylamide is synthesized by a reaction of (meth)acrylic acid with 2-aminoethanol.

Process for the synthesis of anhydrides (meth) acrylic

Abstract: This invention relates to an anhydride synthesis of (meth) acrylic polymer which comprises reacting the (meth) acrylic acid with acetic anhydride in the presence of inhibitor polymerizations. anhydrides (meth) acrylic thus obtained are used in particular reagents in the preparation of (meth) acrylates.

Production of urethane (meth)acrylate compound

Abstract: PURPOSE: To obtain a reaction product having rapid curability and excellent hardness and adhesion to an iron surface and therefore used for adhesives, paints, etc., by reacting a reaction product between a diisocyanate and a spiroglycol with a specified (meth)acrylic monomer. CONSTITUTION: A diisocyanate is reacted with a spiroglycol to form an isocyanate-terminated prepolymer. This prepolymer is reacted with an active hydrogen-containing (meth)acrylic monomer having at least three (meth)acryloyl groups. Examples of said diisocyanates include 2,4-tolylene diisocyanate and 4,4'-diphenylmethane diisocyanate. Examples of said (meth)acrylic monomers having at least three (meth)acryloyl groups include diglycerin tri(meth)acrylate and pentaerythritol tri(meth)acrylate. Said reaction may be performed in the absence of any solvent or in the presence of a solvent such as tetrahydrofuran. The reaction temperature is preferably 80°C or below. COPYRIGHT: (C)1986,JPO&Japio

Production of polyacrylic or polymethacrylic acid hydrazide

Abstract: PURPOSE:To obtain poly(meth)acrylic acid hydrazide useful as a antithrombotic material, high-molecular sizing agent, or the like, by polymerizing a reaction product between hydrazine hydrate and an alkyl (meth)acrylate and/or (meth)acrylic acid. CONSTITUTION:A reaction product obtained by reacting 0.5-1.0mol of hydrazine hydrate with 1mol of a 1-22C alkyl (meth)acrylate (e.g., methyl methacrylate) and/or (meth)acrylic acid is polymerized near room temperature in air in the absence of any catalyst.