Showing papers on "Organomercury Compounds published in 1984"

Organomercury medicinal chemistry. Synthesis and structure of a (β-methoxyethyl)mercury(II) derivative of N(7)-deprotonated theophylline, [Hg(C3H7O)(C7H7N4O2)]

Abstract: Organomercury compounds are widely used in medicinal applications. Alkoxyalkylmercurials have been used as fungicides and bacteriocides and, in addition, a range of diuretics containing substituted (betap-methoxyethyl)mercury(II) groups RCH(OMe)CH2Hg and CH2(OMe)CH(R)Hg, have been extensively used since the 1920's. Theophylline is often administered in conjunction with the mercurial diuretics as its presence greatly enhances diuretic effectiveness, but the nature of any chemical reaction between organomercurials and theophylline has not been established. We report here the isolation of a crystalline complex from the reaction of (beta-methoxyethyl)mercury(II) acetate and theophylline, and a crystallographic determination of the binding site for mercury in the complex. The complex may be regarded as a model for the species formed on co-administration of an organomercury diuretic with theophylline. The structure consists of molecules of [Hg(CH2CH2OCH3)(C7H7N402)] linked into a three-dimensional network by weak intermolecular Hg..O (methoxyethyl) and Hg..N(9) (theophylline) interactions of 2·89(1) and 2·91(1) A respectively. The mercury atom is bound to the deprotonated nitrogen atom N(7), with Hg-N(7) 2·08(1), Hg-C (methoxyethyl) 2·13(2) A and C-Hg-N(7) 173.3(6)°.

Some Rearrangements of Free Alkyl Radicals and Alkyl Cations in Solutions

Abstract: The results of studies of rearrangement reactions by the author and his co-workers during the last 20 years are described. A rearrangement of the n-propyl free radical in solutions as a result of the hydrogen 1,3-shift has been discovered and its characteristic features have been investigated (using carbon-14, deuterium, and tritium). The reaction involving the formation of organomercury compounds from mercury salts of carboxylic acids and peroxides has been studied and a mechanism has been proposed for it. New skeletal rearrangements in the thermal decomposition of cycloalkyl peroxides in benzene and bromoform have been discovered. It has been shown by the method of double 13C NMR that some of the reactions involve the formation of species which manifest properties intermediate between those of free radicals and carbonium ions. The mechanism of the thermolysis of peroxides is considered. The skeletal rearrangements and hydride shifts in the deamination and solvolysis of alicyclic compounds have been studied and a number of rearrangements with 1,2-migration of the halogen and in particular the isomerisation of acyloxybromopropanes in organic solvents, which takes place particularly readily, have been observed. The bibliography includes 103 references.

Reactions of organometallic compounds catalyzed by transition metal complexes. Communication 6. Reactions of organomercury compounds with acid chlorides in the presence of palladium, nickel, and rhodium complexes

Abstract: 1. A study was carried out on the effect of solvent, catalyst, and halide ion additives on the acyldemetallation of organomercury compounds in the presence of palladium, nickel, and rhodium complexes. Optimal conditions were found for carrying out the acyldemercuration both for R2Hg and RHgX, where R=aryl and alkyl groups. 2. Convenient methods were developed for the synthesis of substituted benzophenones, alkylaromatic, unsaturated, and heterocyclic ketones.