Showing papers on "Pulmonary diffusion published in 1986"
TL;DR: Pulmonary diffusion capacity was measured before and 2.1 h after a short maximal arm exercise bout in 11 canoeists and showed a decrease, which may be explained by a calculated 17% increase in alveolar interstitial volume.
Abstract: Oppression of the chest, cough and orthopnea are well known to occur in some athletes after competitions, maybe reflecting an increase in lung water. In order to indicate if lung water increases after maximal exercise we measured pulmonary diffusion capacity before and 2.1 h after a short maximal arm exercise bout in 11 canoeists and showed a decrease of 6.7%. The result may be explained by a calculated 17% increase in alveolar interstitial volume.
39 citations
TL;DR: A physiologically based pharmacokinetic model was used to describe the disposition of morphine in postoperative patients, which allowed simulation of pulmonary diffusion, uptake and elimination and supported conclusions based on model-independent experimental data.
Abstract: The influence of lung uptake and lung clearance on the disposition of morphine was studied in surgical patients. In the postoperative period morphine was given intravenously by a two-rate infusion regimen. Under steady-state conditions samples of mixed central venous blood (pulmonary artery) and peripheral arterial blood (radial artery) were taken simultaneously and at the same time cardiac output was measured. The concentration differences between venous and arterial blood were used to calculate the extraction ratio of morphine across the lung. In all patients there was marked pulmonary uptake, but the concentration differences in most of them were small under steady-state conditions. The extraction ratio (mean +/- SD) across the lung was 0.06 +/- 0.10, implying insignificant lung clearance. However, in two patients, both with diabetes mellitus, there was a significant concentration gradient, indicating that the lung could contribute to the total body elimination of morphine. On the other hand, the total clearance was similar in diabetic and nondiabetic patients (1190 and 1150 ml/min, respectively), implying that pulmonary clearance would have no significant influence on the kinetics of morphine. A physiologically based pharmacokinetic model was used to describe the disposition of morphine in post-operative patients. The model allowed simulation of pulmonary diffusion, uptake and elimination and supported conclusions based on model-independent experimental data.
16 citations