Showing papers on "Radiation-induced lung injury published in 2006"
TL;DR: The current concepts about the pathogenetic mechanisms underlying radiation pneumonitis and fibrosis are presented, and the clinical course of fibrosis, a postulated acute inflammatory stage, and a late fibrotic and irreversible stage are discussed.
Abstract: Radiation pneumonitis and subsequent radiation pulmonary fibrosis are the two main dose-limiting factors when irradiating the thorax that can have severe implications for patients' quality of life. In this article, the current concepts about the pathogenetic mechanisms underlying radiation pneumonitis and fibrosis are presented. The clinical course of fibrosis, a postulated acute inflammatory stage, and a late fibrotic and irreversible stage are discussed. The interplay of cells and the wide variety of molecules orchestrating the immunologic response to radiation, their interactions with specific receptors, and the cascade of events they trigger are elucidated. Finally, the implications of this knowledge with respect to the therapeutic interventions are critically presented.
290 citations
TL;DR: Development of fever and dyspnea, and short interval between the end of radiotherapy and the first radiographic change were associated with fatal radiation-induced lung injury.
56 citations
TL;DR: Normal lung parenchyma is often unavoidably exposed to radiation during thoracic radiotherapy for bronchogenic and systemic neoplasms, and the cellular processes of radiation-induced injury begin within.
Abstract: :Normal lung parenchyma is often unavoidably exposed to radiation during thoracic radiotherapy for bronchogenic and systemic neoplasms. Because the lung is extremely radiosensitive, radiation-induced lung injury occurs commonly. The cellular processes of radiation-induced injury begin within
8 citations