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Paul W. Biddinger
Researcher at University of Cincinnati
Publications - 40
Citations - 4424
Paul W. Biddinger is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Epidermoid carcinoma & Thyroid carcinoma. The author has an hindex of 25, co-authored 40 publications receiving 4283 citations. Previous affiliations of Paul W. Biddinger include University of Cincinnati Academic Health Center.
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Journal ArticleDOI
BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas
Marina N. Nikiforova,Edna Teruko Kimura,Manoj Gandhi,Paul W. Biddinger,Jeffrey A. Knauf,Fulvio Basolo,Zhaowen Zhu,Riccardo Giannini,Giuliana Salvatore,Alfredo Fusco,Massimo Santoro,James A. Fagin,Yuri E. Nikiforov +12 more
TL;DR: BRAF mutations are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas.
Journal ArticleDOI
RAS Point Mutations and PAX8-PPARγ Rearrangement in Thyroid Tumors: Evidence for Distinct Molecular Pathways in Thyroid Follicular Carcinoma
Marina N. Nikiforova,Roy A. Lynch,Paul W. Biddinger,Erik K. Alexander,Gerald W. Dorn,Giovanni Tallini,Todd G. Kroll,Yuri E. Nikiforov +7 more
TL;DR: The results suggest that conventional follicular thyroid carcinomas develop through at least two distinct and virtually nonoverlapping molecular pathways initiated by either RAS point mutation or PAX8-PPAR gamma rearrangement.
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Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas.
Adebowale Adeniran,Zhaowen Zhu,Manoj Gandhi,David L. Steward,James P. Fidler,Thomas J. Giordano,Paul W. Biddinger,Yuri E. Nikiforov +7 more
TL;DR: It is demonstrated that BRAF, RET/PTC, and RAS mutations are associated with distinct microscopic, clinical, and biologic features of thyroid papillary carcinomas.
Journal ArticleDOI
PAX8-PPARγ rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses
TL;DR: The absence of PAX8-PPAR&ggr; rearrangements in Hurthle cell tumors and papillary thyroid carcinomas highlights the differences in the molecular pathogenesis of these thyroid tumors.