Showing papers on "Strychnos potatorum published in 2011"
01 Jan 2011
TL;DR: The study concluded that the seeds of Strychnos potatorum possess marked nephroprotective activity and could have a promising role in the treatment of acute renal injury induced by nephrotoxins, especially gentamicin.
Abstract: The study was carried out to evaluate the nephroprotective activity of ethanolic extract of Strychnos potatorum seeds in rats. Thirty healthy animals of Wister strain were assigned to five groups. Six animals were randomly separated as normal control group, treated only with normal saline. Remaining 24 animals were randomly assigned to four experimental groups of 6 animals, each receiving gentamicin intra-peritoneally. Since 2000 mg/kg of ethanolic extract of Strychnos potatorum did not produce any toxicity, 1/10 th of the dose was fixed. The extract was administered in three dose levels of 100, 200, 300 mg/kg body weight. Pharmacological studies were carried out to evaluate the haematological and biochemical parameters, followed by histopathological examination. The alcoholic extract of Strychnos potatorum at a dose level of 200mg/kg/body weight was found to normalize the raised blood urea, blood protein and serum creatinine. Investigation of the possible protective effect of Strychnos potatorum revealed that 10days administration of 200mg/kg of alcoholic extract along with gentamicin reduced the gentamicin induced renal injury. The study concluded that the seeds of Strychnos potatorum possess marked nephroprotective activity and could have a promising role in the treatment of acute renal injury induced by nephrotoxins, especially gentamicin.
10 citations
TL;DR: The different extracts of S. potatorum seed have potent antianaphylactic activity through mast cell stabilization and inhibition of nitric oxide synthesis through chloroform, petroleum ether, and methanolic extracts.
Abstract: Aim: The antianaphylactic activity of Strychnos potatorum Linn seed extract was evaluated by using compound 48/80 induced anaphylaxis and mast cell stabilization was studied by using peritoneal mast cells of rats. The possible antianaphylactic and mast cell stabilization mechanism was evaluated by using compound 48/80 induced mast cell activation and level of nitric oxide in rat peritoneal mast cells. Materials and Methods: Anaphylactic shock in mice was induced by the intraperitoneal administration of 8 mg/kg compound 48/80, prior to induction of anaphylaxis the animals were treated with S. potatorum Linn. seed extract administered orally 1 h before administration of compound 48/80, the rate mortality was observed in each group of animals. Mast cell stabilization was seen by preincubation of mast cells with the compound 48/80 and the extracts. Results: This study indicates that the chloroform, petroleum ether, and methanolic extracts were shown potent and has significant ( P P Conclusion: We conclude from this study that the different extracts of S. potatorum seed have potent antianaphylactic activity through mast cell stabilization and inhibition of nitric oxide synthesis. The inhibitory effect of S. potatorum Linn. on release of histamine and nitric oxide protects from compound 48/80 induced anaphylactic reaction may be through blocking vasodilatation, decrease vascular resistance, hypotension and tachycardia induced by immunogenic agent used in this study.
7 citations
TL;DR: The results reveal that, the drug treatment decreased the LPO levels in plasma and tissues, either by interception of the formation or by scavenging the active oxygen species, and SPE was found to show higher antioxidant activity when compared with SPP.
Abstract: The Indian system of medicine provides Strychnos potatorum Linn. seeds for the treatment of various ailments like jaundice, bronchitis, diabetes, renal and vesicle calculi, conjunctivitis, chronic diarrhoea, dysentery etc. The present study involves the effect of crude powder (SPP) and aqueous extract (SPE) of S. potatorum Linn seeds on in vivo antioxidant defense system against Freund’s complete adjuvant (FCA) induced arthritis in rats at the dose of 200 mg/kg/p.o for 14 and 28 days and in vitro antioxidant activity against Ferrous thiocyanate (FTC) and Thiobarbiturate (TBA) induced lipid peroxidation. The antioxidant defense system parameters studied in plasma and tissues of arthritic rats were found to be altered significantly. These alterations observed in arthritic rats may be due to the increased oxidative stress in the tissues, which were significantly reduced in SPP and SPE treated arthritic rats. The results reveal that, the drug treatment decreased the LPO levels in plasma and tissues, either by interception of the formation or by scavenging the active oxygen species. The raise in enzymic and nonenzymic antioxidants level may be due to the sparing effect of antioxidant defense system as the drugs SPP and SPE have scavenged the free radicals by various antioxidant phytochemicals like steroids, triterpenes and polyphenolics present in it either by individual or by combined action. In in vitro total antioxidant analysis by FTC and TBA methods, SPE was found to show higher antioxidant activity when compared with SPP.
Key words: Strychnos potatorum, enzymic and non-enzymic antioxidants, free radical scavenging, lipid peroxidation.
7 citations
TL;DR: The morphology and histology of the seeds of Strychnos nux‐vomica, Linn.
Abstract: The morphology and histology of the seeds of Strychnos nux-vomica, Linn., Strychnos nux-blanda, Hill., and Strychnos potatorum, Linn., are described. The diagnostic features by which the two adulterants S. nux-blanda and S. potatorum can be distinguished from the pharmacopoeial drug S. nux-vomica, are noted.
5 citations
TL;DR: SPP and SPE treatment to the arthritic rats normalized the lysosomal enzymes and glycoproteins and increased the collagen content, which may be due to its membrane-stabilizing action and suppression of the collagenases that destroys collagen and bone.
Abstract: The effect of the aqueous extract (SPE) and powder (SPP) of S. potatorum seeds at the dose of 200 mg.kg−1 p.o. were studied in developing and developed stages of Freunds adjuvant (0.1mL) induced arthritic rats for 14 and 28 days respectively. On day 29, the animals were sacrificed and serum and tissue samples were collected for estimation of lysosomal enzymes, glycoproteins and angular cartilage for collagen formation. In both stages of arthritis, the serum and tissue levels showed increased lysosomal enzymes and glycoproteins whereas decreased collagen content in the synovial tissues. SPP and SPE treatment to the arthritic rats normalized the lysosomal enzymes and glycoproteins and increased the collagen content, which may be due to its membrane-stabilizing action and suppression of the collagenases that destroys collagen and bone.
3 citations
TL;DR: In this paper, the removal of Congo red from its aqueous solution using Strychnos potatorum seed powder (SPSP), an Indian seed, used from ancient times for the treatment of turbid water, was highlighted.
Abstract: This study highlights the removal of Congo red from its aqueous solution using Strychnos potatorum seed powder (SPSP), an Indian seed, used from ancient times for the treatment of turbid water. Surface activation of the adsorbent was carried out using ultra sonication techniques. Comparative studies on the uptake of the dye by both unsonicated and sonicated adsorbents were carried out. Experiments were conducted at various initial concentrations of dye and the influence of pH, biomass, temperature and contact time on the uptake of dye by SPSP was studied. High removal efficiency was observed at relatively low concentration of the dye. The optimum pH and temperature for the adsorption process was 6 and 28°C, respectively. The data obtained were found to follow the pseudo first order kinetics and the Boyd's film-diffusion model. The thermodynamic studies showed that the adsorbent was more suitable for the removal of dyes.
1 citations