Showing papers on "Thiazepine published in 1996"

Thiazine or thiazepine derivatives which inhibit NOS

Abstract: A thiazine- or a thiazepine-derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof. wherein R is a hydrogen atom, a substituted or unsubstituted alkyl group, a cycloalkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted aralkyl group, R , R , R , and R , which may be the same or different, respectively are a hydrogen atom, a substituted or unsubstituted alkyl group, A is an oxygen atom, a sulfur atom, or an NH group, m is 0 or 1, and p is 0 or 1, This compound has a nitric oxide synthase inhibition activity.

Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. X--Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure.

Abstract: Some naphtho[1,2,-b]-s-triazolo[4,3-d]-1,4-thiazine and 1,5-thiazepine and s-triazolo[4', 3'-4,5]-1,4-thiazino[3,2-c]quinoline derivatives have been synthesized and tested for their ability to displace [3H]RO 15-1788 binding from bovine brain membranes. Several compounds showed moderate binding affinity for the benzodiazepine receptor.

Mew disulfide compound, production thereof and production of thiazepine derivative by using the same compound

Abstract: PROBLEM TO BE SOLVED: To obtain a new diformyldiphenyldisulfide compound useful as a medicine, an agrochemical agent, a functional material and a synthetic intermediate of 2,3,4,5-tetrahydro-1,4-benzothiazepine useful as a medicine, an agrochmical agent and a function material. SOLUTION: This new disulfide compound is a diformyldiphenyldisulfide compound of formula I (R is H, a halogen, a 1-4C linear or branched chain alkyl, a 1-4C alkoxy or cyano), e.g. 2,2'-diformyl-4,4'-dimethoxydiphenyldisulfide of formula II. The compound of the formula II is obtained by chlorinating a 2-alkylthiobenzaldehyde of formula III and then hydrolyzing the chlorinated compound by using a lower alcohol. A 2,3,4,5-tetrahydro-1,4-benzothiazepine of formula IV is obtained industrially advantageously, in good efficiency and economically by reacting the diformyldiphenyldisulfide compound of the formula I with 2-chloroethylamine or a mineral acid salt thereof in the presence of a base, and then cyclizing the reaction product by using a reducing agent.

Propenethioamides in the Synthesis of Heterocyclic Systems. Synthesis of Pyrrole and 1,4‐Thiazepine Derivatives.

Abstract: The reaction of propenethioamides 1 with bromoketones 2 and 3 led in acidic medium to the formation of 1,4-thiazepines 6 and 7. The pyrrole derivatives 4 and 5 were obtained by reaction of 1 with 2 and 3 in basic medium.

Thiazine- or thiazepine-derivatives

Abstract: A thiazine- or a thiazepine-derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof. wherein R is a hydrogen atom, a substituted or unsubstituted alkyl group, a cycloalkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, or a substituted or unsubstituted aralkyl group, R , R , R , and R , which may be the same or different, respectively are a hydrogen atom, a substituted or unsubstituted alkyl group, A is an oxygen atom, a sulfur atom, or an NH group, m is 0 or 1, and p is 0 or 1, This compound has a nitric oxide synthase inhibition activity.