G
Gino Giannaccini
Researcher at University of Pisa
Publications - 260
Citations - 4853
Gino Giannaccini is an academic researcher from University of Pisa. The author has contributed to research in topics: Serotonin transporter & Receptor. The author has an hindex of 35, co-authored 251 publications receiving 4418 citations. Previous affiliations of Gino Giannaccini include University of Siena.
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Journal ArticleDOI
Tryptophan Biochemistry: Structural, Nutritional, Metabolic, and Medical Aspects in Humans
TL;DR: The role of Trp biochemistry in the pathogenesis of human complex diseases/syndromes primarily involving the gut, neuroimmunoendocrine/stress responses, and the CNS is underscore, supporting the use of -Omics approaches in this field.
Journal Article
Cytokine patterns in fibromyalgia and their correlation with clinical manifestations.
Laura Bazzichi,Alessandro Rossi,Gabriele Massimetti,Gino Giannaccini,T. Giuliano,F. De Feo,Antonio Ciapparelli,Liliana Dell'Osso,Stefano Bombardieri +8 more
TL;DR: The higher levels of cytokines found in FM patients suggest the presence of an inflammatory response system (IRS) and highlight a parallel between the clinical symptoms and biochemical data, which support the hypothesis that cytokines may play a role in the clinical features of fibromyalgia.
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Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.
Carlotta Granchi,Sarabindu Roy,Chiara Giacomelli,Marco Macchia,Tiziano Tuccinardi,Adriano Martinelli,Mario Lanza,Laura Betti,Gino Giannaccini,Antonio Lucacchini,Nicola Funel,Leticia G. Leon,Leticia G. Leon,Elisa Giovannetti,Godefridus J. Peters,Rahul Palchaudhuri,Emilia C. Calvaresi,Paul J. Hergenrother,Filippo Minutolo +18 more
TL;DR: New and efficient N-hydroxyindole-based inhibitors of LDH-A are discovered, which are isoform-selective (overLDH-B) and competitive with both the substrate (pyruvate) and the cofactor (NADH) and they proved to be particularly effective under hypoxic conditions.
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Proteome analysis of whole saliva: A new tool for rheumatic diseases – the example of Sjögren's syndrome
Laura Giusti,Chiara Baldini,Laura Bazzichi,Federica Ciregia,Ilaria Tonazzini,G. Mascia,Gino Giannaccini,Stefano Bombardieri,Antonio Lucacchini +8 more
TL;DR: The WS protein pattern was altered in pSS patients compared to controls, with a decrease in some of the typical salivary proteins, and a set of differentially expressed proteins were related to acute and chronic inflammation while some others were involved in oxidative stress injury.
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A relationship between oxytocin and anxiety of romantic attachment
Donatella Marazziti,Bernardo Dell'Osso,Bernardo Dell'Osso,Stefano Baroni,Francesco Mungai,M. Catena,Paola Rucci,Francesco Albanese,Gino Giannaccini,Laura Betti,L. Fabbrini,Paola Italiani,Alessandro Del Debbio,Antonio Lucacchini,Liliana Dell'Osso +14 more
TL;DR: The results showed that attachment anxiety and oxytocin are positively linked in romantic attachment to a statistically significant degree and the authors suggest the hypothesis that this link represents one of the biological processes resulting in those rewarding emotions related to romantic attachment.