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Showing papers on "Thienamycin published in 2003"

Journal Article•DOI•
The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya

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Luz Elena Núñez1, Carmen Méndez1, Alfredo F. Braña1, Gloria Blanco1, José A. Salas1 •
University of Oviedo1
01 Apr 2003-Chemistry & Biology
TL;DR: Involvement of the cluster in thienamycin biosynthesis was demonstrated by insertional inactivation of several genes generating thiensamycin nonproducing mutants.

106 citations

Patent•
Gene cluster for thienamycin biosynthesis, genetic manipulation and utility

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Luz E. Núñez1, Gloria Blanco1, Alfredo F. Braña1, Carmen Méndez1, José A. Salas1 •
University of Oviedo1
26 Feb 2003
TL;DR: Isolation, cloning and sequencing of the cluster of genes involved in the biosynthesis of the carbapenem thienamycin by streptomyces cattleya are described in this paper.
Abstract: Isolation, cloning and sequencing of the cluster of genes involved in the biosynthesis of the carbapenem thienamycin by streptomyces cattleya, and the use of those genes to increase thienamycin production, and/or related antibiotics, in the producing strains, and obtaining new derivatives by means of genetic manipulation which implies gene expression, mutagenesis by gene replacement and combinatorial biosynthesis.

13 citations