Showing papers on "Topographic map (neuroanatomy) published in 2021"
TL;DR: Here, recent progress is reviewed on the study of neural circuits involved in decision making in the mouse olfactory system on the basis of animal studies and human studies.
Abstract: In mammals, odor information detected by olfactory sensory neurons is converted to a topographic map of activated glomeruli in the olfactory bulb. Mitral cells and tufted cells transmit signals seq...
36 citations
TL;DR: In this paper, the authors used visual stimulation to control the visually-evoked correlation structure of neural activity in ectopic ipsilaterally projecting (ipsi) retinal ganglion cell axons with respect to their neighboring contralateral eye inputs in the optic tectum of albino Xenopus laevis tadpoles.
Abstract: During development, patterned neural activity in input neurons innervating their target, instructs topographic map refinement. Axons from adjacent neurons, firing with similar patterns of neural activity, converge onto target neurons and stabilize their synapses with these postsynaptic partners (Hebbian plasticity). On the other hand, non-correlated firing of inputs promotes synaptic weakening and exploratory axonal growth (Stentian plasticity). We used visual stimulation to control the visually-evoked correlation structure of neural activity in ectopic ipsilaterally projecting (ipsi) retinal ganglion cell axons with respect to their neighboring contralateral eye inputs in the optic tectum of albino Xenopus laevis tadpoles. Multiphoton imaging of the ipsi axons in the live tadpole, combined with manipulation of brain-derived neurotrophic factor (BDNF) signaling, revealed that presynaptic p75NTR and TrkB both promoted axonal branch addition during Stentian plasticity, whereas predominantly postsynaptic BDNF signaling mediated activity-dependent Hebbian suppression of axon branch addition. Additionally, we found that BDNF signaling is required for local suppression of branch loss induced by correlated firing.
2 citations