Showing papers on "TRPV published in 1999"
TL;DR: This channel, which is named growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions and augments calcium entry through GRC by regulating trafficking of the channel.
Abstract: Calcium plays a critical part in the regulation of cell growth, and growth factors stimulate calcium entry into cells through calcium-permeable channels However, the molecular nature and regulation of calcium-permeable channels are still unclear at present Here we report the molecular characterization of a calcium-permeable cation channel that is regulated by insulin-like growth factor-I (IGF-I) This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel
450 citations