Showing papers on "Withania somnifera published in 1970"
TL;DR: Withania somnifera Dun (Solanaceae) growing in the southern coastal plane of Israel constitutes a new chemotype and is designated as chemotype III as mentioned in this paper, and the following structures have been assigned to seven of the above compounds: Withanolide G, 20α,27dihydroxy-1-oxo-20R,22R-witha-2,5,8(14),24-tetraenolide (2,2,14)
104 citations
TL;DR: Three new withanolides (C 28 steroids possessing a 6-membered ring lactone in the side chain) have been isolated from Withania somnifera (Solanaceae) growing in South Africa and characterized as 4β-hydroxy-1-oxo-5β,6β-epoxywitha-2,24-dienolide (IIIa), 4β,20α,(R )dihydroxy- 1-oxoxo,5β-6β -epoxy with-2-enoline (IVa
48 citations
TL;DR: The inhibition of Ehrlich ascites tumor growth is thought to represent a combined effect of withaferin A action and immune reactions.
Abstract: Withaferin A, a steroidal lactone with carcinostatic properties, isolated from the leaves of Withania somnifera Dun., produced a mitotic arrest in the metaphase of dividing Ehrlich ascites carcinoma cells. In addition this compound also induced vacuolization of the cytoplasm. A single dose of withaferin A, administered 24 hours after Ehrlich ascites implantation, caused growth reduction followed by disappearance of the tumor in 80% of the mice. These mice were found to be resistant to rechallenge with Ehrlich ascites tumor cells. The inhibition of Ehrlich ascites tumor growth is thought to represent a combined effect of withaferin A action and immune reactions.
34 citations
TL;DR: The derivation of anaferine from lysine and acetate has been demonstrated in intact Withania somnifera plants and N-Methylisopel letierine is shown to be the immediate precursor of psueudopelletierine.
Abstract: The biosynthesis of isopeletierine [1-(2-piperidyl)propan-2-one], N-methylisopelletierine, and pseudopelletierine (9-methyl-9-azabicylo[3,3,1]nonan-3-one) in intact Punica granatum plants has been studied N-Methylisopelletierine is shown to be derived from lysine and acetate Acetate is shown to be the precursor of the three-carbon unit in isopelletierine and pseudopelletierine N-Methylisopelletierine is shown to be the immediate precursor of psueudopelletierineThe derivation of anaferine from lysine and acetate has been demonstrated in intact Withania somnifera plants Isopelletierine has also been shown to be a precursor of anaferine
12 citations