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A. Boncoraglio
Researcher at University of Milan
Publications - 12
Citations - 1088
A. Boncoraglio is an academic researcher from University of Milan. The author has contributed to research in topics: Protein degradation & BAG3. The author has an hindex of 12, co-authored 12 publications receiving 940 citations. Previous affiliations of A. Boncoraglio include University Medical Center Groningen & University of Florence.
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Journal ArticleDOI
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
Valeria Crippa,Daniela Sau,Paola Rusmini,A. Boncoraglio,E. Onesto,E. Bolzoni,Mariarita Galbiati,Elena Fontana,Marianna Marino,Serena Carra,Caterina Bendotti,Silvia De Biasi,Angelo Poletti +12 more
TL;DR: Using motor neuronal fALS models, it is demonstrated that HspB8 decreases aggregation and increases mutant SOD1 solubility and clearance, without affecting wild-type S OD1 turnover, and the pharmacological modulation of HSpB8 expression in motor neurons may have important implications to unravel the molecular mechanisms involved both in fALS and in sALS.
Journal ArticleDOI
BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch.
Melania Minoia,A. Boncoraglio,Jonathan Vinet,Federica Francesca Morelli,Jeanette F. Brunsting,Angelo Poletti,Sabine Krom,Eric Reits,Harm H. Kampinga,Serena Carra +9 more
TL;DR: It is proposed that following proteasome impairment, increasing the BAG3/BAG1 ratio ensures the “BAG-instructed proteasomal to autophagosomal switch and sorting” (BIPASS).
Journal ArticleDOI
Identification of the Drosophila Ortholog of HSPB8 IMPLICATION OF HSPB8 LOSS OF FUNCTION IN PROTEIN FOLDING DISEASES
Serena Carra,A. Boncoraglio,Bart Kanon,Jeanette F. Brunsting,Melania Minoia,Anil Rana,Michel J. Vos,Kay Seidel,Ody C. M. Sibon,Harm H. Kampinga +9 more
TL;DR: The current data further support the link between the HSPB8-BAG3 complex, autophagy, and folding diseases and demonstrate that impairment or loss of function of H SPB8 might accelerate the progression and/or severity of folding diseases.
Journal ArticleDOI
The HSPB8‐BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases
Kay Seidel,Jonathan Vinet,W. F. A. den Dunnen,Ewout R. Brunt,Melanie Meister,A. Boncoraglio,Marianne P. Zijlstra,Hendrikus Boddeke,Udo Rüb,Harm H. Kampinga,Serena Carra +10 more
TL;DR: K. Kampinga and S. Carra (2012) Neuropathology and Applied Neurobiology38, 39–53
Journal ArticleDOI
The family of mammalian small heat shock proteins (HSPBs) : Implications in protein deposit diseases and motor neuropathies
TL;DR: This review summarizes the current knowledge about some of the best characterized functions of the HSPBs (e.g. role in cytoskeleton stabilization, chaperone function, anti-aggregation and anti-apoptotic activities), also highlighting differences in the properties of the various HSPB and how these may counteract protein aggregation diseases.