H
Hendrikus Boddeke
Researcher at University Medical Center Groningen
Publications - 146
Citations - 11321
Hendrikus Boddeke is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Microglia & Chemokine receptor. The author has an hindex of 54, co-authored 146 publications receiving 10052 citations. Previous affiliations of Hendrikus Boddeke include University of Amsterdam & University of Groningen.
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Journal ArticleDOI
Microglia in Physiology and Disease
TL;DR: The diversity of microglia phenotypes and their responses in health, aging, and disease are described and treatment options that modulate microglial phenotypes are discussed.
Journal ArticleDOI
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
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Neuronal ‘On’ and ‘Off’ signals control microglia
TL;DR: Neurons should be envisaged as key immune modulators in the brain and contribute to the inflammatory milieu of the central nervous system.
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Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
Frank Szulzewsky,Andreas Pelz,Xi Feng,Michael Synowitz,Darko Markovic,Thomas Langmann,Inge R. Holtman,Xi Wang,Bart J. L. Eggen,Hendrikus Boddeke,Dolores Hambardzumyan,Susanne A. Wolf,Helmut Kettenmann +12 more
TL;DR: It is demonstrated that the expression of Gpnmb and Spp1 is highly upregulated in both murine and human glioma-associated microglia/macrophage phenotype including a mixture of M1 and M2a,b,c-specific genes.
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Identification of a microglia phenotype supportive of remyelination
Marta Olah,Sandra Amor,Sandra Amor,Nieske Brouwer,Jonathan Vinet,Bart J. L. Eggen,Knut Biber,Knut Biber,Hendrikus Boddeke +8 more
TL;DR: The notion that the primary function of microglia is the maintenance of tissue homeostasis and the support of regeneration already at the earliest stages in the development of demyelinating lesions is reinforced.