Caterina Bendotti

TL;DR: Using motor neuronal fALS models, it is demonstrated that HspB8 decreases aggregation and increases mutant SOD1 solubility and clearance, without affecting wild-type S OD1 turnover, and the pharmacological modulation of HSpB8 expression in motor neurons may have important implications to unravel the molecular mechanisms involved both in fALS and in sALS.

TL;DR: These second and improved guidelines are dedicated to the memory of Sean F. Scott and will help to establish SOPs for translational research for other neurological diseases within the next few years.

TL;DR: A role of IL-1 in the neuronal mechanisms related to beta-amyloid protein deposition in AD is suggested, as seen in neurons, glial and endothelial cells.

TL;DR: In this article, the authors showed that the activation of the mitochondrial permeability transition pore may be an important factor triggering the cascade leading to progressive motor neuron death in the spinal cord.

TL;DR: The expression of mutant SOD1 has a substantial impact on astrocyte protein secretion pathways, contributing to motor neuron pathology and disease spread and new therapeutic approaches should target exosomes to contain disease progression.