A.D. Michie

TL;DR: Analysis of the structural families generated by CATH reveals the prominent features of protein structure space and a database of well-characterised protein structure families will facilitate the assignment of structure-function/evolution relationships to both known and newly determined protein structures.

TL;DR: A consensus approach for the assignment of structural domains in proteins is presented, which combines a number of previously published algorithms, and takes advantage of the elevated accuracy obtained when assignments from the individual algorithms are in agreement.

TL;DR: The extent to which the contemporary dataset of protein structures can be segregated into four structural "classes" as originally defined by Levitt & Chothia in 1976 is examined and a simple method presented for the assignment of protein domains into these classes.

TL;DR: A recently established facility to search the CATH database with the coordinates of a newly determined structure and use automatic sequence and structure comparison methods to assign this new structure to one or more of the domain families within CATH.