A. De Vos

TL;DR: A resolution of the normal human c-H-ras oncogene protein lacking a flexible carboxyl-terminal 18 residue reveals that the protein consists of a six-stranded beta sheet, four alpha helices, and nine connecting loops that indicate additional regions in the molecule that may possibly participate in other cellular functions.

TL;DR: In this paper, the authors examined the anaplerosis of glucose carbon in purified rat islets using specific 14C-labeled glucose tracers and concluded that 25% of the glucose carbon entering the Krebs cycle via anaphylaxis is channeled into protein synthesis.

TL;DR: Comparison with GTP-analog complexes of ras proteins suggests that the valine side-chain may inhibit GTP hydrolysis in two possible ways: (1) interacting directly with the gamma-phosphate and altering its orientation or the conformation of protein residues around the phosphates; and/or (2) preventing either the departure of gamma- phosphate on GTP Hydrolysis or the entrance of a nucleophilic group to attack the gamma.

TL;DR: Comparison of glucose metabolism in two beta‐cell subpopulations separated on the basis of the presence or absence of a metabolic redox shift at 7.5 mM glucose shows heterogeneity in glucose metabolism cannot be attributed to differences in GLUT2 mRNA levels or in glucose transport.

TL;DR: The clinical outcome of 1- cell biopsy was significantly better than that of 2-cell biopsy, even when adjusted for availability of genetically transferable embryos.