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A. Dessa Sadovnick
Researcher at University of British Columbia
Publications - 136
Citations - 11284
A. Dessa Sadovnick is an academic researcher from University of British Columbia. The author has contributed to research in topics: Multiple sclerosis & Population. The author has an hindex of 44, co-authored 135 publications receiving 10539 citations. Previous affiliations of A. Dessa Sadovnick include Vancouver Coastal Health & University of Manitoba.
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Journal ArticleDOI
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
Matt Baker,Ian R. A. Mackenzie,Stuart Pickering-Brown,Jennifer Gass,Rosa Rademakers,Caroline Lindholm,Julie S. Snowden,Jennifer Adamson,A. Dessa Sadovnick,Sara Rollinson,Ashley Cannon,Emily Dwosh,David Neary,Stacey Melquist,Anna Richardson,Dennis W. Dickson,Zdenek Berger,Jason L. Eriksen,Todd Robinson,Cynthia Zehr,Chad A. Dickey,Richard Crook,Eileen McGowan,David M. A. Mann,Bradley F. Boeve,Howard Feldman,Mike Hutton +26 more
TL;DR: It is demonstrated that in multiple FTD families with significant evidence for linkage to the same region on chromosome 17q21, FTD is caused by mutations in progranulin (PGRN) that are likely to create null alleles and identified mutations in PGRN as a cause of neurodegenerative disease.
Journal ArticleDOI
Sex ratio of multiple sclerosis in Canada: a longitudinal study
Sarah M. Orton,Blanca M. Herrera,Irene M. Yee,William Valdar,Sreeram V. Ramagopalan,A. Dessa Sadovnick,George C. Ebers +6 more
TL;DR: The substantial increase in the female to male sex ratio in Canada seems to result from a disproportional increase in incidence of multiple sclerosis in women, which implies that a large proportion of several sclerosis cases may be preventable in situ.
Journal ArticleDOI
Vascular Factors and Risk of Dementia: Design of the Three-City Study and Baseline Characteristics of the Study Population
Marilyn Antoniak,Maura Pugliatti,Richard Hubbard,John Britton,Stefano Sotgiu,A. Dessa Sadovnick,Irene M.L. Yee,Miguel A. Cumsille,Jorge A. Bevilacqua,Sarah Burdett,Lesley A. Stewart,Neil Pickering,Nino Khetsuriani,Eva S. Quiroz,Robert C. Holman,Larry J. Anderson,Rosalind Gait,Claire Maginnis,Sarah Lewis,Gustavo C. Román,Violeta Díaz,Torgeir Engstad,Ove Almkvist,Matti Viitanen,Egil Arnesen,Demosthenes B. Panagiotakos,Christina Chrysohoou,Christos Pitsavos,Alessandro Menotti,Anastasios Dontas,John Skoumas,Christodoulos Stefanadis,Pavlos Toutouzas,Amanda S. Persad,Todd Stedeford,Seigo Tanaka,Liping Chen,Marek Banasik,M. Alessandra Sotgiu,Charles M. Poser,Giulio Rosati,Ian Lawson +41 more
TL;DR: In this article, the authors describe the baseline characteristics of the participants in the Three-City (3C) Study, a study aiming to evaluate the risk of dementia and cognitive impairment attributable to vascular factors.
Journal ArticleDOI
Genetics of multiple sclerosis
TL;DR: To overcome the confounding effects of genetic complexity, MS genetic research needs to take advantage of clinical and epidemiological information to better homogenize study samples and shed some light on the mild to moderate susceptibility loci affecting the MS patient population.
Journal ArticleDOI
Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D
Sreeram V. Ramagopalan,Narelle J. Maugeri,Lahiru Handunnetthi,Lahiru Handunnetthi,Matthew R. Lincoln,Matthew R. Lincoln,S M Orton,S M Orton,David A. Dyment,David A. Dyment,Gabriele C. DeLuca,Gabriele C. DeLuca,Blanca M. Herrera,Blanca M. Herrera,Michael J. Chao,Michael J. Chao,A. Dessa Sadovnick,George C. Ebers,George C. Ebers,Julian C. Knight +19 more
TL;DR: In this article, a single MHC vitamin D response element (VDRE) was found to interact with inherited factors and sought responsive regulatory elements in the MHC class II region.