A
A G Tse
Researcher at Harvard University
Publications - 3
Citations - 472
A G Tse is an academic researcher from Harvard University. The author has contributed to research in topics: T-cell receptor & CD3. The author has an hindex of 3, co-authored 3 publications receiving 461 citations.
Papers
More filters
Journal ArticleDOI
A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments.
Hui-Hsin Chang,Z Bao,Y Yao,A G Tse,E C Goyarts,M Madsen,E Kawasaki,P P Brauer,J C Sacchettini,Stanley G. Nathenson +9 more
TL;DR: 30-amino acid-long segments are added to the carboxyl termini of alpha and beta extracellular domains via a cleavable flexible linker to be broadly useful in the efficient production and purification of TCRs as well as other heterodimeric proteins.
Journal ArticleDOI
Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.
Jia-huai Wang,Kap Lim,Alex Smolyar,M Teng,M Teng,Jin-huan Liu,A G Tse,Rebecca E. Hussey,Yasmin Chishti,Cole T. Thomson,Robert M. Sweet,Stanley G. Nathenson,Hsiu-Ching Chang,James C. Sacchettini,Ellis L. Reinherz +14 more
TL;DR: It is shown that quaternary structures of TCRs vary significantly even when they bind the same MHC molecule, as manifested by a unique twisting of the V module relative to the C module.
Journal ArticleDOI
Identification of a common docking topology with substantial variation among different tcr-peptide-mhc complexes
M.-K. Teng,Alex Smolyar,A G Tse,Jin-huan Liu,J.-H. Liu,Rebecca E. Hussey,Stanley G. Nathenson,Hsiu-Ching Chang,Ellis L. Reinherz,Jia-huai Wang +9 more
TL;DR: Comparison of the structure of the N15 TCR-VSV8-H-2Kb complex revealed a common docking mode, regardless of TCR specificity or species origin, in which the TCR variable Valpha domain overlie the MHC alpha2 helix and the Vbeta domain overlies the M HC alpha1 helix.