A
A. Le Saux
Researcher at Centre national de la recherche scientifique
Publications - 4
Citations - 254
A. Le Saux is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Mitochondrion & Inner mitochondrial membrane. The author has an hindex of 3, co-authored 4 publications receiving 254 citations.
Papers
More filters
Journal ArticleDOI
The mitochondrial ADP/ATP carrier: Structural, physiological and pathological aspects
C. Fiore,Véronique Trézéguet,A. Le Saux,Pierre Roux,Christine Schwimmer,A.C. Dianoux,Florence Noël,G.J-M. Lauquin,Gérard Brandolin,Pierre V. Vignais +9 more
TL;DR: The fluorometric approach, using the tryptophanyl residues of the yeast carrier as intrinsic fluorescence probes, was combined to a mutagenesis approach to elucidate the ADP/ATP transport mechanism at the molecular level to develop a method to quantify the carrier protein in muscular biopsies.
Journal ArticleDOI
Fluorometric Titration of the Mitochondrial ADP/ATP Carrier Protein in Muscle Homogenate with Atractyloside Derivatives
Pierre Roux,A. Le Saux,C. Fiore,Christine Schwimmer,A.C. Dianoux,Véronique Trézéguet,Pierre V. Vignais,Guy J.-M. Lauquin,Gérard Brandolin +8 more
TL;DR: Mant- ATR and N-ATR can be considered as convenient, reliable, and sensitive probes to quantify the amount of ADP/ATP carrier and detect a putative carrier protein deficiency in biopsy samples from human patients suffering from myopathies with no clear identified etiology.
Journal ArticleDOI
Conformational changes of the yeast mitochondrial adenosine diphosphate/adenosine triphosphate carrier studied through its intrinsic fluorescence. 2. Assignment of tryptophanyl residues of the carrier to the responses to specific ligands
Pierre Roux,A. Le Saux,Véronique Trézéguet,C. Fiore,Christine Schwimmer,A.C. Dianoux,Pierre V. Vignais,Guy J.-M. Lauquin,Gérard Brandolin +8 more
TL;DR: The different fluorescence responses of the three Trp residues of Anc2 variants to ATP, CATR, and BA are in agreement with distinct binding sites for these ligands and distinct conformations of the carrier protein recognizing specifically CATR or BA.
Book ChapterDOI
Conformational changes of the beef heart and yeast mitochondrial ADP/ATP carrier
Gérard Brandolin,A. Le Saux,Pierre Roux,Véronique Trézéguet,C. Fiore,Christine Schwimmer,A.C. Dianoux,Guy J.-M. Lauquin,Pierre V. Vignais +8 more
TL;DR: Chemical, immunochemical, enzymatic, fluorometric and genetic approaches have been used to investigate conformational changes of the ADP/ATP carrier that are thought to participate in the transport process.