A. M. J. Shapiro

TL;DR: The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass.

TL;DR: In an attempt to reduce the variability in the yields of human islet isolations and to identify donor factors that were potentially deleterious, retrospectively reviewed 153 human islets isolations in the center over a 3-year period suggests an improved approach to the prediction of successful islet isolation from human pancreases.

TL;DR: Controlled perfusion via the pancreatic duct allows the effective delivery of the enzyme achieving maximal distension to all regions of the pancreas leading to an increased recovery of the islets with no detrimental effect on subsequent in vitro islet function.

TL;DR: Pancreatic MSCs residing within the adult exocrine pancreas could represent a progenitor cell, which when further manipulated could result in the production of functional islet beta-cells.

TL;DR: In this article, islet transplant recipients were screened for HLA antibodies posttransplant by flow-based methods and 29 patients developed de novo donor specific antibodies (DSA) post-transplant.