S
Sharleen Imes
Researcher at University of Alberta
Publications - 34
Citations - 3355
Sharleen Imes is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 19, co-authored 31 publications receiving 3191 citations. Previous affiliations of Sharleen Imes include Alberta Health Services & University of Alberta Hospital.
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Journal ArticleDOI
Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
Edmond A. Ryan,Jonathan R. T. Lakey,Ray V. Rajotte,Gregory S. Korbutt,Tatsuya Kin,Sharleen Imes,Alex Rabinovitch,John F. Elliott,David L. Bigam,Norman M. Kneteman,Garth L. Warnock,Ingrid Larsen,A. M. J. Shapiro +12 more
TL;DR: Islet transplantation has successfully corrected labile type 1 diabetes and problems with hypoglycemia, and the results show persistent insulin secretion, which is consistent with good glycemic control.
Journal ArticleDOI
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
Edmond A. Ryan,Jonathan R. T. Lakey,Breay W. Paty,Sharleen Imes,Gregory S. Korbutt,Norman M. Kneteman,David L. Bigam,Ray V. Rajotte,A. M. James Shapiro +8 more
TL;DR: The results indicate that prolonged insulin independence can be achieved after islet transplantation, and there are some risks associated acutely with the procedure, and hypercholesterolemia and hypertension are treatable concerns on longer-term follow-up.
Journal ArticleDOI
Short-Term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes
TL;DR: These results demonstrate that in newly diagnosed type 2 diabetes with elevated fasting glucose levels, a 2- to 3-week course of intensive insulin therapy can successfully lay a foundation for prolonged good glycemic control.
Journal ArticleDOI
Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome
Cale Street,Jonathan R. T. Lakey,A. M. James Shapiro,Sharleen Imes,Ray V. Rajotte,Edmond A. Ryan,James Lyon,Tatsuya Kin,Jose G. Avila,Toshiaki Tsujimura,Gregory S. Korbutt +10 more
TL;DR: T careful assessment of islet graft composition is needed in a clinical transplantation program to accurately estimate islet purity and assess the contribution of other cell types present, such as islet progenitor cells.
Journal ArticleDOI
Defects in Insulin Secretion and Action in Women With a History of Gestational Diabetes
Edmond A. Ryan,Sharleen Imes,Dating Liu,Ruth McManus,Diane T. Finegood,Kenneth S. Polonsky,Jeppe Sturis +6 more
TL;DR: It is concluded that Ultradian insulin secretory oscillations during constant glucose infusion are normal in women with a history of GDM, and defects in insulin secretion and action in post-GDM subjects who are at high risk for the development of NIDDM are found.