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David L. Bigam
Researcher at University of Alberta
Publications - 193
Citations - 9559
David L. Bigam is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Liver transplantation. The author has an hindex of 39, co-authored 174 publications receiving 8795 citations. Previous affiliations of David L. Bigam include Mackenzie Investments & University of Alberta Hospital.
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Journal ArticleDOI
Five-Year Follow-Up After Clinical Islet Transplantation
Edmond A. Ryan,Breay W. Paty,Peter A. Senior,David L. Bigam,Eman Alfadhli,Norman M. Kneteman,Jonathan R. T. Lakey,A. M. James Shapiro +7 more
TL;DR: In conclusion, islet transplantation can relieve glucose instability and problems with hypoglycemia and point to the need for further progress in the availability of transplantable islets, improving islet engraftment, preserving islet function, and reducing toxic immunosuppression.
Journal ArticleDOI
Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
Edmond A. Ryan,Jonathan R. T. Lakey,Ray V. Rajotte,Gregory S. Korbutt,Tatsuya Kin,Sharleen Imes,Alex Rabinovitch,John F. Elliott,David L. Bigam,Norman M. Kneteman,Garth L. Warnock,Ingrid Larsen,A. M. J. Shapiro +12 more
TL;DR: Islet transplantation has successfully corrected labile type 1 diabetes and problems with hypoglycemia, and the results show persistent insulin secretion, which is consistent with good glycemic control.
Journal ArticleDOI
Successful islet transplantation: continued insulin reserve provides long-term glycemic control.
Edmond A. Ryan,Jonathan R. T. Lakey,Breay W. Paty,Sharleen Imes,Gregory S. Korbutt,Norman M. Kneteman,David L. Bigam,Ray V. Rajotte,A. M. James Shapiro +8 more
TL;DR: The results indicate that prolonged insulin independence can be achieved after islet transplantation, and there are some risks associated acutely with the procedure, and hypercholesterolemia and hypertension are treatable concerns on longer-term follow-up.
Journal ArticleDOI
Gastric adenocarcinoma: review and considerations for future directions.
TL;DR: This update reviews the epidemiology and surgical management, and the controversies of gastric adenocarcinoma, and provides the relevance of outcome data to surgical decision-making and discusses the application of gene-expression analysis to clinical practice.
Journal ArticleDOI
Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation
Edmond A. Ryan,Tami Shandro,Kristy Green,Breay W. Paty,Peter A. Senior,David L. Bigam,A. M. James Shapiro,Marie-Christine Vantyghem +7 more
TL;DR: The HYPO score and LI provide measures of the extent of problems with hypoglycemia and glycemic lability, respectively, complement the clinical assessment of the problems with glucose control before islet transplantation, and will allow comparison of selection of subjects for transplants between centers.