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A. M. J. Shapiro
Researcher at University of Alberta
Publications - 32
Citations - 6745
A. M. J. Shapiro is an academic researcher from University of Alberta. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 18, co-authored 32 publications receiving 6428 citations.
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Journal ArticleDOI
Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen
A. M. J. Shapiro,Jonathan R. T. Lakey,Edmond A. Ryan,Gregory S. Korbutt,Ellen L. Toth,Garth L. Warnock,Norman M. Kneteman,Ray V. Rajotte +7 more
TL;DR: The observations in patients with type 1 diabetes indicate that islet transplantation can result in insulin independence with excellent metabolic control when glucocorticoid-free immunosuppression is combined with the infusion of an adequate islet mass.
Journal ArticleDOI
Variables in organ donors that affect the recovery of human islets of Langerhans.
Lakey,Garth L. Warnock,Ray V. Rajotte,Suarez-Alamazor Me,Ziliang Ao,A. M. J. Shapiro,N. M. Kneteman +6 more
TL;DR: In an attempt to reduce the variability in the yields of human islet isolations and to identify donor factors that were potentially deleterious, retrospectively reviewed 153 human islets isolations in the center over a 3-year period suggests an improved approach to the prediction of successful islet isolation from human pancreases.
Journal ArticleDOI
Intraductal collagenase delivery into the human pancreas using syringe loading or controlled perfusion.
Lakey,Garth L. Warnock,A. M. J. Shapiro,Gregory S. Korbutt,Ziliang Ao,Norman M. Kneteman,Ray V. Rajotte +6 more
TL;DR: Controlled perfusion via the pancreatic duct allows the effective delivery of the enzyme achieving maximal distension to all regions of the pancreas leading to an increased recovery of the islets with no detrimental effect on subsequent in vitro islet function.
Journal ArticleDOI
Expansion of mesenchymal stem cells from human pancreatic ductal epithelium
Karen L. Seeberger,Jannette M. Dufour,A. M. J. Shapiro,Jonathan R. T. Lakey,Ray V. Rajotte,Gregory S. Korbutt +5 more
TL;DR: Pancreatic MSCs residing within the adult exocrine pancreas could represent a progenitor cell, which when further manipulated could result in the production of functional islet beta-cells.
Journal ArticleDOI
High risk of sensitization after failed islet transplantation.
Patricia Campbell,Peter A. Senior,Abdul Salam,K. LaBranche,David L. Bigam,Norman M. Kneteman,Sharleen Imes,A. Halpin,Edmond A. Ryan,A. M. J. Shapiro +9 more
TL;DR: In this article, islet transplant recipients were screened for HLA antibodies posttransplant by flow-based methods and 29 patients developed de novo donor specific antibodies (DSA) post-transplant.