A. Mantovani

TL;DR: The capacity to produce IL-6 may represent an important mechanism by which endothelial cells participate in inflammatory and immune reactions, and is defined as a communication signal between vascular and immunocompetent cells.

TL;DR: Analysis of migration across polycarbonate and nitrocellulose filters of human peripheral blood monocytes and polymorphonuclear leukocytes revealed that maximal induction of migration required a positive concentration gradient between the lower and upper compartments and that TNF elicited an actual chemotactic response in phagocytes.

TL;DR: G- CSF and GM-CSF induce endothelial cells to express an activation/differentiation program (including proliferation and migration) related to angiogenesis, and the combination of a nonangiogenic dose of bFGF with G-CSf resulted in an angiogenic response higher than that elicited by either individual cytokines.

TL;DR: Recombinant M-CSF did not elicit a migratory response in large granular lymphocytes and in endothelial cells under conditions in which appropriate reference attractants were active, and may play a role in the selective recruitment from the blood compartment of mononuclear phagocytes to amplify resistance against certain noxious agents.

TL;DR: The mononuclear phagocyte system can autonomously regulate the extravasation and activation of immature elements of the same lineage, a key event in inflammation and immunity.