G
Giuseppe Peri
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 118
Citations - 10820
Giuseppe Peri is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: PTX3 & Pentraxins. The author has an hindex of 58, co-authored 118 publications receiving 10379 citations. Previous affiliations of Giuseppe Peri include Leiden University Medical Center & University of Turin.
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Journal ArticleDOI
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Cecilia Garlanda,Emilio Hirsch,Silvia Bozza,Antonietta Salustri,Marika De Acetis,Rachele Nota,Alessia Maccagno,Federica Riva,Barbara Bottazzi,Giuseppe Peri,Andrea Doni,Luca Vago,Marina Botto,Rita De Santis,Paolo Carminati,Gregorio Siracusa,Fiorella Altruda,Annunciata Vecchi,Luigina Romani,Alberto Mantovani,Alberto Mantovani +20 more
TL;DR: The long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus.
Journal ArticleDOI
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
Sébastien Jaillon,Giuseppe Peri,Yves Delneste,Isabelle Frémaux,Andrea Doni,Federica Moalli,Cecilia Garlanda,Luigina Romani,Hugues Gascan,Silvia Bellocchio,Silvia Bozza,Marco A. Cassatella,Pascale Jeannin,Alberto Mantovani +13 more
TL;DR: The long pentraxin (PTX) 3 is produced by macrophages and myeloid dendritic cells in response to Toll-like receptor agonists and represents a nonredundant component of humoral innate immunity against selected pathogens.
Journal ArticleDOI
Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.
Ferruccio Breviario,E. d’Aniello,Josée Golay,Giuseppe Peri,Barbara Bottazzi,Amos Marc Bairoch,Salvatore Saccone,R Marzella,V Predazzi,Mariano Rocchi +9 more
TL;DR: Differential screening of a cDNA library constructed from human umbilical vein endothelial cells exposed for 1 h to interleukin-1 beta has led to the identification of a novel gene (PTX3) related to pentaxins, a subclass of acute phase proteins.
Journal ArticleDOI
Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction
Roberto Latini,Aldo P. Maggioni,Giuseppe Peri,Lucio Gonzini,Donata Lucci,Paolo Mocarelli,Luca Vago,Fabio Pasqualini,Stefano Signorini,Dario Soldateschi,Lorenzo Tarli,Carlo Schweiger,Claudio Fresco,Rossana Cecere,Gianni Tognoni,Alberto Mantovani +15 more
TL;DR: In a representative contemporary sample of patients with MI with ST elevation, the acute-phase protein PTX3 but not the liver-derived short pentraxin CRP or other cardiac biomarkers (NT-proBNP, TnT, CK) predicted 3-month mortality after adjustment for major risk factors and other acute- phase prognostic markers.
Journal ArticleDOI
PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans
Giuseppe Peri,Martino Introna,Domenico Corradi,Giuseppe Iacuitti,Stefano Signorini,Fausto Avanzini,Fabrizio Pizzetti,Aldo P. Maggioni,Tiziano Moccetti,Marco Metra,Livio Dei Cas,Pietro Ghezzi,Jean D. Sipe,Gianpietro Re,Giorgio Olivetti,Alberto Mantovani,Roberto Latini +16 more
TL;DR: PTx3 is present in the intact myocardium, increases in the blood of patients with AMI, and disappears from damaged myocytes, suggesting that PTX3 is an early indicator of myocyte irreversible injury in ischemic cardiomyopathy.