M
Marina Ziche
Researcher at University of Siena
Publications - 222
Citations - 16951
Marina Ziche is an academic researcher from University of Siena. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 61, co-authored 214 publications receiving 16150 citations. Previous affiliations of Marina Ziche include University of Turin & University of Göttingen.
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Journal ArticleDOI
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
Federico Bussolino,M. F. Di Renzo,Marina Ziche,E Bocchietto,Martina Olivero,Luigi Naldini,Giovanni Gaudino,Luca Tamagnone,A Coffer,Paolo M. Comoglio +9 more
TL;DR: Data show that HGF is an in vivo potent angiogenic factor and in vitro induces endothelial cells to proliferate and migrate and lacks activities related to hemostasis-thrombosis, inflammation and endothelium cells accessory functions.
Journal ArticleDOI
Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.
Marina Ziche,Lucia Morbidelli,Rangana Choudhuri,H. T. Zhang,Sandra Donnini,Harris J. Granger,Roy Bicknell +6 more
TL;DR: It is concluded that NO is a downstream imperative of VEGF-, but not bFGF-induced angiogenesis, and it is proposed that the NO synthase/guanylate cyclase pathway is a potential target for controlling tumorAngiogenesis in response to V EGF.
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Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.
Marina Ziche,Lucia Morbidelli,Emanuela Masini,Sandra Amerini,Harris J. Granger,C.A. Maggi,Pierangelo Geppetti,Fabrizio Ledda +7 more
TL;DR: Data indicate that NO production induced by vasoactive agents, such as SP, functions as an autocrine regulator of the microvascular events necessary for neovascularization and mediates angiogenesis.
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VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
TL;DR: It is concluded that VEGF upregulates ecNOS enzyme and elicits a biphasic stimulation of endothelial NO production, and regulates endothelial production of NO.
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A novel vascular endothelial growth factor encoded by Orf virus, VEGF‐E, mediates angiogenesis via signalling through VEGFR‐2 (KDR) but not VEGFR‐1 (Flt‐1) receptor tyrosine kinases
Marlene Meyer,Matthias Clauss,Albrecht Lepple-Wienhues,Johannes Waltenberger,Hellmut G. Augustin,Marina Ziche,Christa Lanz,Mathias Büttner,Hanns Joachim Rziha,Christoph Dehio +9 more
TL;DR: VEGF‐E is thus a potent angiogenic factor selectively binding to VEGF receptor‐2 alone can efficiently stimulate angiogenesis, and strongly indicates that activation of V EGF receptor-2 aloneCan efficiently stimulateAngiogenesis.