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A. N. Chuvilin
Researcher at Russian Academy of Sciences
Publications - 13
Citations - 165
A. N. Chuvilin is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Oligonucleotide & DNA. The author has an hindex of 5, co-authored 13 publications receiving 148 citations. Previous affiliations of A. N. Chuvilin include Peninsular Malaysia & Engelhardt Institute of Molecular Biology.
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Journal ArticleDOI
DNA modification of live cell surface
TL;DR: A novel approach for the attachment of DNA fragments to the surface of live cells allows rapid and simple DNA multicoding of the cell surface and opens new opportunities in manipulating with cell–cell interactions.
Journal ArticleDOI
Synthesis of triazole-linked oligonucleotides with high affinity to DNA complements and an analysis of their compatibility with biosystems.
Anna M. Varizhuk,Anna M. Varizhuk,Dmitry N. Kaluzhny,Roman A. Novikov,Alexandr O. Chizhov,Igor P. Smirnov,A. N. Chuvilin,Olga N. Tatarinova,Gleb Y. Fisunov,Galina E. Pozmogova,V. L. Florentiev +10 more
TL;DR: These new oligonucleotide analogues with triazole internucleotide linkages with remote from the 3'-terminus were synthesized and their hybridization properties were studied, suggesting that they are among the most promising Triazole DNA mimics characterized to date.
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Comparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamer.
Olga N. Tatarinova,Vladimir B. Tsvetkov,Dmitry Basmanov,Nikolay A. Barinov,Igor P. Smirnov,Edward N. Timofeev,Dmitry N. Kaluzhny,A. N. Chuvilin,Dmitry V. Klinov,Anna M. Varizhuk,Galina E. Pozmogova +10 more
TL;DR: Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer and their relative advantages and disadvantages as well as their potential in drug design and fundamental studies were analyzed.
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Complexes of telomeric oligonucleotide d(TTAGGG)4 with the new recombinant protein vector PGEk carrying nucleic acids into proliferating cells
TL;DR: The secondary structure of DNA and the number of protein subunits were established for the biologically active complexes PGEk-TMO and PGEK-TMS, which efficiently pass across the membrane of cancer cells and inhibit their proliferation.
Journal Article
[Complexes of telomeric oligonucleotide d(TTAGGG)4 with the new recombinant protein PGEk--nucleic acid carrier into proliferating cells].
TL;DR: The tertiary structure of DNA and the number of adsorbed PGEk molecules formed biologically active compounds P GEk: TMO and PGEK: TMS were defined, which are able to penetrate through the membrane of proliferating cells and to suppress their growth.